Results 261 to 270 of about 527,772 (339)

Metabolic Stress‐Induced Choline Kinase α (CHKA) Activation in Endothelial Subpopulation Contributes to Diabetes‐Associated Microvascular Dysfunction

Advanced Science, EarlyView.
This study uncovers CHKA as a pivotal driver of vascular dysfunction in diabetic retinopathy and highlights its role in endothelial dysfunction through NAD⁺‐SIRT1‐Notch signaling. Single‐cell and functional analyses, combined with clinical and genetic validation, suggest CHKA as a promising therapeutic target for the prevention and treatment of ...
Ling Ren, Linyu Zhang, Yun Bai, Chang Huang, Xiaosa Li, Fanfei Ma, Wan Mu, Mudi Yao, Chang Jiang, Xiangjun Chen, Qin Jiang, Biao Yan   +11 more
wiley   +1 more source

Advances in research regarding epithelial-mesenchymal transition and prostate cancer. [PDF]

Front Cell Dev Biol
Wei X, Liu R, Li W, Yu Q, Yang QT, Li T.
europepmc   +1 more source

Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range

Advanced Science, EarlyView.
ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen, Junyuan Xue, Ziying Wang, Jinyuan Sun, Yinglu Cui, Tong Zhu, Huaiyi Yang, Ming Li, Bian Wu   +8 more
wiley   +1 more source

KAT5 promotes tumor growth in androgen-independent prostate cancer by facilitating aerobic glycolysis. [PDF]

Transl Oncol
He W, Zhao J, Dai J, Fang C, Huang X, Wang C, Gao Y, Sun F, Xie X.   +8 more
europepmc   +1 more source

Effects of the 5-HT2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine (PCA) in Mice.

, 2001
Jun Yamada, Yumi Sugimoto, Minako Ohkura, Kiyo Inoue   +3 more
openalex   +2 more sources

A Mitochondria‐Targeted Nanozyme Platform for Multi‐Pathway Tumor Therapy via Ferroptosis and Cuproptosis Regulation

Advanced Science, EarlyView.
This work reports a mitochondria‐targeted nanozyme platform, MIL‐Cu1.8S‐TPP/FA, which induces potent cuproptosis via localized delivery of Cu1.8S nanodots to mitochondria. Surface‐anchoring these nanodots onto MIL‐88B metal‐organic frameworks enhances both passive and active tumor targeting.
Chenguang Liu, Lingxiao Guo, Yuying Cheng, Jingjie Gao, Hanling Pan, Jiayi Zhu, Danting Li, Liqing Jiao, Caiyun Fu   +8 more
wiley   +1 more source

Principal Component Analysis Based Quaternion-Valued Medians for Non-Invasive Blood Glucose Estimation. [PDF]

Sensors (Basel)
Feng J, Ling BW.
europepmc   +1 more source

Reliability of Ship Equipment and Influence of Failures on Navigation-II : Actual Situation of Ship Equipment Failures and Statistical Study of SRIC Information by PCA

, 2001
Nobuo Kiriya
openalex   +2 more sources

Tracing and Capturing the Epiblast Pluripotency of Sheep Preimplantation Embryos

Advanced Science, EarlyView.
This study performs a comprehensive single‐cell transcriptome analysis of sheep embryos from embryonic (E) day 1 to E14 to elucidate the mechanism of early lineage specification and the pluripotency changes (naïve, formative, and primed) of epiblast.
Jinying Zhang, Runbo Li, Ruijie Luo, Qiang Zhang, Zimo Zhao, Haishen Xu, Minglei Zhi, Wenjie Jiang, Meng Wang, Xinze Chen, Zhiqiang Feng, Yingjie Wang, Yuhan Yang, Pengcheng He, Hanyue Su, Tianzhi Chen, Shunxin Wang, Yixuan Yao, Jinghui Yang, Fan Zhao, Tingting Li, Haitao Wang, Xiaosheng Zhang, Jinlong Zhang, Qiuyue Liu, Shuai Gao, Yuchang Yao, Jianyong Han, Suying Cao   +28 more
wiley   +1 more source

Associations Between Long-Term Exposure to Air Pollutants and Prostate Cancer in a Large Taiwanese Population. [PDF]

Int J Med Sci
Geng JH, Li CY, Wu MT, Chen SC, Huang SP.   +4 more
europepmc   +1 more source