Results 291 to 300 of about 1,072,724 (364)

Single‐Cell Transcriptomics Unravels Growth Factor Erv1‐Like Mediated Ferroptosis as a Key Driver of Intestinal Epithelial Dysfunction in Ulcerative Colitis

Advanced Science, EarlyView.
Single‐cell transcriptomic profiling of ulcerative colitis (UC) tissues identified downregulation of GFER in intestinal epithelial cells. Mechanistically, GFER interacts with PCBP1 to help maintain intracellular iron homeostasis and may also reduce lipid peroxidation by activating the PGC‐1α/PPARγ signaling pathway, thereby inhibiting ferroptosis ...
Ya Song, Fangyan Tan, Qian Song, Xiaohui Liao, Zhechuan Mei, Lin Lv   +5 more
wiley   +1 more source

[⁹⁹ᵐTc]Tc-PSMA-I&S SPECT/CT quantitative parameters for risk stratification and metastasis prediction in primary prostate cancer: a retrospective study. [PDF]

Front Med (Lausanne)
Li M, Gao Z, Sun J, Li X, Liang C, He T.
europepmc   +1 more source

Effects of the 5-HT2 Receptor Antagonist, Ritanserin on Hyperthermia and Depletion of 5-HT in Frontal Cortex Induced by a 5-HT Releasing Drug, p-Chloroamphetamine (PCA) in Mice.

, 2001
Jun Yamada, Yumi Sugimoto, Minako Ohkura, Kiyo Inoue   +3 more
openalex   +2 more sources

Polyhalogenated Carbazole Impairs Dopaminergic Neurons through Dysregulation of Liquid–Liquid Phase Separation in Caenorhabditis elegans

Advanced Science, EarlyView.
Polyhalogenated carbazoles (PHCZ), persistent environmental contaminants, preferentially accumulate in neuronal tissues. Studies using Caenorhabditis elegans and human neuronal cell lines reveal that PHCZ induce dopaminergic neurodegeneration by promoting liquid–liquid phase separation of α‐synuclein, reducing condensate fluidity, impairing ...
Yuhang Luo, Hongbo Xu, Pei Peng, Xinhe Lu, Qian Zhou, Ziqing Gao, Cheng Tang, Hongyan Yin, Ying Cai, Gaga Mahai, Zhiqiang Zhu, Zuojun Liu, Hanzeng Li, Shunqing Xu   +13 more
wiley   +1 more source

Cancer-related identity and advanced old age - analysis of prostate cancer survivors after radical prostatectomy over the age of 75. [PDF]

BMC Geriatr
Jahnen M, Bierwirth C, Meissner VH, Dinkel A, Schiele S, Schulwitz H, Gschwend JE, Herkommer K.   +7 more
europepmc   +1 more source

Reliability of Ship Equipment and Influence of Failures on Navigation-II : Actual Situation of Ship Equipment Failures and Statistical Study of SRIC Information by PCA

, 2001
Nobuo Kiriya
openalex   +2 more sources

Single‐Cell Transcriptome Analysis Reveals That Hmga2 Regulates Neuroinflammation and Retinal Function by Modulating Müller Cell Autophagy Through PI3K/AKT Signaling Following MCAO‐Induced Retinal Ischemia

Advanced Science, EarlyView.
Employing snRNA‐seq post‐MCAO‐induced retinal ischemia (RI), this study revealed a novel Hmga2‐high Müller cell subpopulation. Hmga2 knockout alleviated neuroinflammation and RI symptoms, potentially by binding PI3K and regulating Müller cell autophagy.
Weihao Lv, Juzheng Yuan, Zhe Ruan, Ya‐nan Dou, Hongchen Zhang, Xiaowei Fei, Leiying Chen, Zehan Zhang, Kai Yang, Xiuquan Wu, Zhou Fei, Fei Fei   +11 more
wiley   +1 more source

A review of exercise-induced epigenetic modifications in prostate tissue: implications for gene expression and tumor progression in prostate cancer. [PDF]

Cancer Cell Int
Ye K, Ke Z, Gesang W, Liang K, Malek M.
europepmc   +1 more source

A Study on the Cell Layer Patterns of a Citrus Periclinal Chimera Reveals β‐Cryptoxanthin Regulation in Citrus Fruits

Advanced Science, EarlyView.
Researchers have identified a citrus chimera with distinctive tissue origins and carotenoid profiles. It is discovered that fruit tissues develop from all three cell layers but in different proportions. A key transcription factor, MYB107, regulates β‐cryptoxanthin production by directly activating carotenoid biosynthesis genes, explaining why some ...
Chi Zhang, Kaijie Zhu, Zhehui Zhang, Huiyu Ji, Qun Wu, Lin Zhang, Fuzhi Ke, Gang Wang, Min Zhang   +8 more
wiley   +1 more source

Thyroid hormone receptor beta signaling is a targetable driver of prostate cancer growth. [PDF]

Mol Cancer
Fesiuk A, Pölöske D, de Araujo ED, Frere GA, Wright TB, Tin G, Raouf YS, Olaoye OO, Park JS, Blavet N, Tichý B, Schlederer M, Högler S, Wolf M, Philippe C, Aksoy O, Varady A, Mata AM, Varenicja M, Szabó B, Weiss T, Wasinger G, Redmer T, Neubauer HA, Susani M, Spielvogel CP, Ning J, Dahlhoff M, Schepelmann M, Kennedy R, Moriggl R, Brown G, Persson J, Gerner C, Bystry V, Hollóczki O, Heery DM, Gunning PT, Merkel O, Hantusch B, Kenner L.   +40 more
europepmc   +1 more source