Results 41 to 50 of about 896,372 (322)

The Turbulence Spectrum of Molecular Clouds in the Galactic Ring Survey: A Density-Dependent PCA Calibration [PDF]

, 2011
Turbulence plays a major role in the formation and evolution of molecular clouds. The problem is that turbulent velocities are convolved with the density of an observed region.
Brunt, Christopher, Federrath, Christoph, Heyer, Mark, Jackson, James, Klessen, Ralf, Roman-Duval, Julia   +5 more
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Novel use of waste sawdust in green stormwater infrastructure (GSI)

Results in Engineering
As urban populations grow, finding appropriate strategies for managing waste and stormwater is becoming increasingly more challenging. While the incorporation of waste materials into concrete has been studied for structural components, the use of waste ...
Ebru Özer, Berrin Tansel
doaj   +1 more source

N-Dimensional Principal Component Analysis [PDF]

, 2010
In this paper, we first briefly introduce the multidimensional Principal Component Analysis (PCA) techniques, and then amend our previous N-dimensional PCA (ND-PCA) scheme by introducing multidirectional decomposition into ND-PCA implementation.
Yu, Hongchuan
core  

Validation of nonlinear PCA

, 2012
Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity.
A Herman, A Ilin, AN Gorban, B Chalmond, B Christiansen, B Efron, B Schölkopf, BW Lu, D DeMers, JB Tenenbaum, LK Saul, M Scholz, MA Kramer, Matthias Scholz, MR Hestenes, ND Lawrence, P Demartines, R Hecht-Nielsen, S Girard, S Harmeling, S Mika, ST Roweis, T Hastie, T Kohonen, WW Hsieh, WW Hsieh, WW Hsieh   +26 more
core   +1 more source

Embedding Principal Component Analysis for Data Reductionin Structural Health Monitoring on Low-Cost IoT Gateways [PDF]

, 2019
Principal component analysis (PCA) is a powerful data reductionmethod for Structural Health Monitoring. However, its computa-tional cost and data memory footprint pose a significant challengewhen PCA has to run on limited capability embedded platformsin ...
Abdelgawad A., Allen-Zhu Z., Hardt Moritz, Li J., Mitliagkas Ioannis, Reyer M., Rooshenas A., Tokognon C. Arcadius, Vaswani N.   +8 more
core   +2 more sources

The PCa Tumor Microenvironment [PDF]

Cancer Microenvironment, 2011
The tumor microenvironment (TME) is a very complex niche that consists of multiple cell types, supportive matrix and soluble factors. Cells in the TME consist of both host cells that are present at tumor site at the onset of tumor growth and cells that are recruited in either response to tumor- or host-derived factors.
Joseph L, Sottnik, Jian, Zhang, Jill A, Macoska, Evan T, Keller   +3 more
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Metabolite Profiling of Three Curcuma Species (Zingiberaceae) Based on H-NMR Spectroscopy

Alchemy, 2019
Genus Curcuma, Zingiberaceae, is a typical medicinal plant in tropical region especially in Indonesia. It has been studied to have antioxidant, antimicrobial, antitumor, anti-inflammatory and anticancer activities.
Dinar Sari Cahyaningrum Wahyuni, Mutya Puti Wardianti, Yudi Rinanto, Soerya Dewi Marliyana   +3 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source