Results 51 to 60 of about 914,283 (289)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Novel use of waste sawdust in green stormwater infrastructure (GSI)

Results in Engineering
As urban populations grow, finding appropriate strategies for managing waste and stormwater is becoming increasingly more challenging. While the incorporation of waste materials into concrete has been studied for structural components, the use of waste ...
Ebru Özer, Berrin Tansel
doaj   +1 more source

An \u3cem\u3eIn Vitro\u3c/em\u3e Spectroscopic Analysis to Determine Whether Para-Chloroaniline Is Produced from Mixing Sodium Hypochlorite and Chlorhexidine [PDF]

, 2010
Introduction: The purpose of this in vitro study was to determine whether para-chloroaniline (PCA) is formed through the reaction of mixing sodium hypochlorite (NaOCl) and chlorhexidine (CHX).
Sem, Daniel S., Thomas, John
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

PCA and t-SNE Implementation for KNN Hypertension Classification Visualization

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
Hypertension is a condition that, if allowed to increase, can significantly injure internal organs due to high blood pressure. The objective of this study is to use the K-Nearest Neighbor (KNN) algorithm along with PCA and t-SNE to accurately identify ...
Andi Aulia Cahyana Resky, Jessica Crisfin Lapendy, Andi Akram Nur Risal, Dewi Fatmarani Surianto, Abdul Wahid   +4 more
doaj   +1 more source

Hybrid modeling and prediction of oyster norovirus outbreaks

Journal of Water and Health, 2021
This paper presents a hybrid model for predicting oyster norovirus outbreaks by combining the Artificial Neural Networks (ANNs) and Principal Component Analysis (PCA) methods and using the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite ...
Shima Shamkhali Chenar, Zhiqiang Deng
doaj   +1 more source

N-Dimensional Principal Component Analysis [PDF]

, 2010
In this paper, we first briefly introduce the multidimensional Principal Component Analysis (PCA) techniques, and then amend our previous N-dimensional PCA (ND-PCA) scheme by introducing multidirectional decomposition into ND-PCA implementation.
Yu, Hongchuan
core  

Principal Component Analysis studies of turbulence in optically thick gas

, 2015
In this work we investigate the Principal Component Analysis (PCA) sensitivity to the velocity power spectrum in high opacity regimes of the interstellar medium (ISM). For our analysis we use synthetic Position-Position-Velocity (PPV) cubes of fractional
Burkhart, Blakesley, Correia, Caio, De Medeiros, José Renan, Lazarian, Alex, Pogosyan, Dmitri   +4 more
core   +1 more source

PCA of PCA: Principal Component Analysis of Partial Covering Absorption in NGC 1365 [PDF]

, 2014
We analyse 400 ks of XMM-Newton data on the active galactic nucleus NGC 1365 using principal component analysis (PCA) to identify model independent spectral components.
Fabian, A. C., Parker, M. L., Risaliti, G., Walton, D. J.   +3 more
core   +2 more sources