Results 51 to 60 of about 387,650 (261)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Spectral–Spatial Attention-Guided Multi-Resolution Network for Pansharpening

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Pansharpening is a technique that combines high-resolution panchromatic (PAN) images with low-resolution multispectral (MS) images to produce high-resolution MS (HRMS) images.
Shen Xu, Shengwei Zhong, Hui Li, Chen Gong   +3 more
doaj   +1 more source

A Novel & Efficient Fusion Based Image Retrieval Model for Speedy Image Recovery [PDF]

EAI Endorsed Transactions on Scalable Information Systems, 2020
An efficient and novel image retrieval system is framed here, which retrieve images from massive datasets to overcome the constraints of efficiency and retrieval time.
Shefali Dhingra, Poonam Bansal
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Novel use of waste sawdust in green stormwater infrastructure (GSI)

Results in Engineering
As urban populations grow, finding appropriate strategies for managing waste and stormwater is becoming increasingly more challenging. While the incorporation of waste materials into concrete has been studied for structural components, the use of waste ...
Ebru Özer, Berrin Tansel
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

PCA and t-SNE Implementation for KNN Hypertension Classification Visualization

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi)
Hypertension is a condition that, if allowed to increase, can significantly injure internal organs due to high blood pressure. The objective of this study is to use the K-Nearest Neighbor (KNN) algorithm along with PCA and t-SNE to accurately identify ...
Andi Aulia Cahyana Resky, Jessica Crisfin Lapendy, Andi Akram Nur Risal, Dewi Fatmarani Surianto, Abdul Wahid   +4 more
doaj   +1 more source

Calculating Demands of Fruit Trees for Water Using Neural Network Algorithm

Guan'gai paishui xuebao, 2022
【Objective】 Knowing the demand of crops for water is a prerequisite in designing saving-water irrigation and improving water management. The aim of this paper is to study the accuracy and reliability of the neural network algorithm for estimating water ...
HE Shulin, LIU Huimin, JIN Liqiang, LIU Yong   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source