Results 51 to 60 of about 919,275 (319)

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Denizli (Tavas) Badem (Prunus amygdalus L.) Genotiplerinin Morfolojik ve Pomolojik Karakterlerinin Belirlenmesi

Turkish Journal of Agriculture: Food Science and Technology
Bu çalışmada, Denizli ili Tavas ilçesinde doğal olarak yetişen 38 badem genotipinin pomolojik ve kolorimetrik özellikleri incelenmiştir. İncelenen genotiplerde meyve ağırlığı 3,00-6,87 g, iç ağırlığı 0,26-1,98 g ve iç oranı %13,26-43,30 arasında değişim ...
Levent Kırca
doaj   +1 more source

The Turbulence Spectrum of Molecular Clouds in the Galactic Ring Survey: A Density-Dependent PCA Calibration [PDF]

, 2011
Turbulence plays a major role in the formation and evolution of molecular clouds. The problem is that turbulent velocities are convolved with the density of an observed region.
Brunt, Christopher, Federrath, Christoph, Heyer, Mark, Jackson, James, Klessen, Ralf, Roman-Duval, Julia   +5 more
core   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Mikrodalga Ön İşlemli Vakumlu Kurutma Yönteminin Portakal Dilimlerinin Renk ve Fenolik Bileşen Profili Üzerine Etkileri: Çok Değişkenli Analiz Yaklaşımı

Turkish Journal of Agriculture: Food Science and Technology
Bu çalışmada, portakal dilimlerinin kalite özellikleri üzerine farklı sıcaklık (60, 70 ve 80°C) ve mutlak basınç (15 ve 30 kPa) kombinasyonlarında gerçekleştirilen vakumlu kurutma (VK) işlemlerinde mikrodalga ön işleminin (90 W, 30 dk) etkileri ...
Büşra Acoğlu Çelik, Tuğba Özdal, Azime Özkan Karabacak, Perihan Yolcı Ömeroğlu   +3 more
doaj   +1 more source

N-Dimensional Principal Component Analysis [PDF]

, 2010
In this paper, we first briefly introduce the multidimensional Principal Component Analysis (PCA) techniques, and then amend our previous N-dimensional PCA (ND-PCA) scheme by introducing multidirectional decomposition into ND-PCA implementation.
Yu, Hongchuan
core  

Embedding Principal Component Analysis for Data Reductionin Structural Health Monitoring on Low-Cost IoT Gateways [PDF]

, 2019
Principal component analysis (PCA) is a powerful data reductionmethod for Structural Health Monitoring. However, its computa-tional cost and data memory footprint pose a significant challengewhen PCA has to run on limited capability embedded platformsin ...
Abdelgawad A., Allen-Zhu Z., Hardt Moritz, Li J., Mitliagkas Ioannis, Reyer M., Rooshenas A., Tokognon C. Arcadius, Vaswani N.   +8 more
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Analysis of Data and Feature Processing on Stroke Prediction using Wide Range Machine Learning Model

JOIN: Jurnal Online Informatika
Stroke is a disease which cause the death of brain cells, so that the part of the body controlled by the brain loses its function. If not treated immediately, this disease can cause long-term disability, brain damage, and death.
Untari Novia Wisesty, Tjokorda Agung Budi Wirayuda, Febryanti Sthevanie, Rita Rismala   +3 more
doaj   +1 more source