Results 71 to 80 of about 896,372 (322)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Energy Consumption Modeling in Activated Sludge Process Using Coupling PCA-ANFIS Approach [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2019 The main challenge in Wastewater Treatment Plants (WWTP) by activated sludge process is the reduction of the energy consumption that varies according to the pollutant load of influent.
Radia Maachou +3 more
doaj
International Journal of Food Properties, 2021 Jujube has received more and more attention due to their nutritional value and pharmacological effects. This study evaluated the quality of different varieties of jujube by comparing the main active components and antioxidant activities of thirty-seven ...
Yanlei Zhang +3 more
doaj +1 more source
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
Oceanological and Hydrobiological Studies, 2022 This study aims to examine the physicochemical parameters of seawater (temperature, pH, salinity, dissolved oxygen, suspended particulate matter, ammonium-nitrogen, nitrite-nitrogen, nitrate-nitrogen, and phosphate-phosphorus, burnable organic matter in ...
Çulha Saniye Türk +3 more
doaj +1 more source
Information-theoretically Optimal Sparse PCA
, 2014 Sparse Principal Component Analysis (PCA) is a dimensionality reduction technique wherein one seeks a low-rank representation of a data matrix with additional sparsity constraints on the obtained representation. We consider two probabilistic formulations
Deshpande, Yash, Montanari, Andrea
core +1 more source
Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations
FEBS Open Bio, EarlyView.Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro +8 more
wiley +1 more source
Phase Transitions in Sparse PCA
, 2015 We study optimal estimation for sparse principal component analysis when the number of non-zero elements is small but on the same order as the dimension of the data. We employ approximate message passing (AMP) algorithm and its state evolution to analyze
Krzakala, Florent +2 more
core +2 more sources
$e$PCA: High dimensional exponential family PCA
The Annals of Applied Statistics, 2018 Many applications, such as photon-limited imaging and genomics, involve large datasets with noisy entries from exponential family distributions. It is of interest to estimate the covariance structure and principal components of the noiseless distribution.
Liu, Lydia T. +2 more
openaire +4 more sources
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source