Results 71 to 80 of about 919,275 (319)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Le fait du prince comme cause d’admission au régime de force majeure en droit minier congolais : notion, portée et implications [PDF]

Mouvements et Enjeux Sociaux
La succession d’évènements tragiques au cours des XX et XXIe siècles a mis en évidence l’importance de la gestion des risques avec notamment des risques industriels, financiers, sociétaux (les soulèvements), sanitaires (pandémie de covid-19), ou encore ...
Patrick BONDONGA LESAMBO , Kevin ESHIMATA NGIMBI   +1 more
doaj  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

HAND HUMAN RECOGNITION BERDASARKAN GEOMETRI TELAPAK TANGAN MENGGUNAKAN PRINCIPAL COMPONENT ANALYSIS

Simetris: Jurnal Teknik Mesin, Elektro dan Ilmu Komputer, 2019
Sistem pengenalan diri merupakan sebuah sistem yang dapat digunakan untuk mengenali identitas sesorang yang dapat dilakukan secara otomatis menggunakan komputer.
Nurul Fadillah, Imanuddin Imanuddin, Dewi Lestari   +2 more
doaj   +1 more source

Calculating Demands of Fruit Trees for Water Using Neural Network Algorithm

Guan'gai paishui xuebao, 2022
【Objective】 Knowing the demand of crops for water is a prerequisite in designing saving-water irrigation and improving water management. The aim of this paper is to study the accuracy and reliability of the neural network algorithm for estimating water ...
HE Shulin, LIU Huimin, JIN Liqiang, LIU Yong   +3 more
doaj   +1 more source

Fair principal component analysis (PCA): minorization-maximization algorithms for Fair PCA, Fair Robust PCA and Fair Sparse PCA

, 2023
In this paper we propose a new iterative algorithm to solve the fair PCA (FPCA) problem. We start with the max-min fair PCA formulation originally proposed in [1] and derive a simple and efficient iterative algorithm which is based on the minorization-maximization (MM) approach.
Babu, Prabhu, Stoica, Petre
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Active components and antioxidant activity of thirty-seven varieties of Chinese jujube fruits (Ziziphus jujuba Mill.)

International Journal of Food Properties, 2021
Jujube has received more and more attention due to their nutritional value and pharmacological effects. This study evaluated the quality of different varieties of jujube by comparing the main active components and antioxidant activities of thirty-seven ...
Yanlei Zhang, Xin Sun, Sriram K. Vidyarthi, Rentang Zhang   +3 more
doaj   +1 more source

Determining Principal Component Cardinality through the Principle of Minimum Description Length

, 2019
PCA (Principal Component Analysis) and its variants areubiquitous techniques for matrix dimension reduction and reduced-dimensionlatent-factor extraction. One significant challenge in using PCA, is thechoice of the number of principal components.
A Blumer, AJ Donald, AP Dawid, AR Barron, C Eckart, DC Hoyle, IT Jolliffe, J Josse, J Rissanen, J Rissanen, J Rissanen, J Rissanen, JI Myung, M Mitzenmacher, M Zhu, MH Hansen, T Hastie, TM Cover, Y Choi   +18 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source