Results 121 to 130 of about 6,861,462 (220)

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

, 2014
Although the mechanism of Aβ action in the pathogenesis of Alzheimer's disease (AD) has remained elusive, it is known to increase the expression of the antagonist of canonical wnt signalling, Dickkopf-1 (Dkk1), whereas the silencing of Dkk1 blocks Aβ ...
C Hooper (9155960), EM Ribe (21863570), M Robinson (11004687), R Williamson (7655078), W Noble (21863600), R Al-Shawi (21863573), J Stephenson (7715702), C Fernandes (4048552), S Kellie (13687915), R Wroe (21863585), J-P Brion (21863609), R Dobson (2567176), A Usardi (21863597), PM Nolan (21863576), A Hodges (21863606), R Killick (7647119), JP Simons (21863612), K Leroy (21863591), S Lovestone (10497245), K Lunnon (18628609), S Furney (21863582), K Lin (7725194), G Breen (7655030), CH Reynolds (21863603), B Malik (21857711), AWM To (21863588), A Lourdusamy (21863579), C Bazenet (13425411), M Causevic (21863594)   +28 more
core  

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Pentachlorophenol (PCP) and pentachloroanisole (PCA) [Elektronisk resurs]

, 2017
Pentachlorophenol (PCP) was first synthesized for use as a fungicide for wood protection in the 1930s. PCP affects most organisms by decoupling oxidative phosphorylation and other crucial biochemical functions (IPCS, 1987; UNEP, 2013e).
Muir, Derek,, Kylin, Henrik,
core  

Dynamic Regulation of Supramolecular Chirality in an Amphiphilic Dimeric Macrocycle Through Azobenzene‐Based Photoisomerization

Advanced Science, EarlyView.
A stimuli‐responsive supramolecular system has been rationally designed enabling hierarchical control over supramolecular handedness. This hybrid architecture retains orthogonal host‐guest properties and displays unique amphiphilicity‐directed chiral self‐assembly.
Minzan Zuo, Yi Shi, Xueqi Tian, Tao Zhang, Jianmin Jiao, Yuhong Shen, Yutong Xie, Jianwen Wei, Xiao‐Yu Hu   +8 more
wiley   +1 more source

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Vinylidene and carbyne complexes derived from the reactions of OsCl(PPh3)(PCP) (PCP=2,6-(PPh2CH2)(2)CsH3) with terminal acetylenes [PDF]

, 2000
Treatment of OsCl2(PPh3)(3) with 1,3-(PPh2CH2)(2)C6H4 led to the formation of the coordinatively unsaturated complex OsCl(PPh3)(PCP) (PCP = 2,6-(PPh2CH2)(2)C6H3).
Wong, W. T., Zhou, Z. Y., 温庭斌, Wen, T. B., Cheung, Y. K., Jia, G. C., Yao, J. Z.   +6 more
core  

Strongly prime PCP words

, 1995
We consider words which are prime (no suffix/subword/scattered subword removed from them can lead to a solution) for all instances of PCP for which they are solutions.
Marjo Lipponen, Gheorghe Päun, Päun, Gheorghe, Lipponen, Marjo   +3 more
core   +1 more source

Multifactor Risk Stratification for Post‐Transplant Alcohol Relapse Using Abstinence, Psychosocial, and Socioeconomic Factors

Annals of Gastroenterological Surgery, EarlyView.
Alcohol relapse after liver transplantation is difficult to predict using abstinence duration alone. We developed a multifactor model integrating abstinence duration, psychosocial risk (SIPAT), and socioeconomic context (AUC 0.70). This approach may support individualized risk assessment and tailored follow‐up intensity; external validation is needed ...
Ayato Obana, Garren Montgomery, Miho Akabane, Matthew Hamilton, Navdeep Singh, Musab Alebrahim, Austin Schenk, Sylvester Black, Kenneth Washburn, Khalid Mumtaz   +9 more
wiley   +1 more source

How does the Kids SIPsmartER program impact the sugar‐sweetened beverage intake of students: An investigation beyond total treatment effect in randomized controlled trial

American Journal of Agricultural Economics, EarlyView.
Abstract This study develops and empirically estimates a structural framework to decompose the causal pathways of multilevel behavioral interventions targeting adolescent health behaviors. We apply this framework to the Kids SIPsmartER (KSS) program, a 6‐month, school‐based intervention evaluated through a clustered randomized controlled trial in rural
Naveen Abedin, Wen You, Annie Reid, Kathleen Porter, Brittany Kirkpatrick, Jamie Zoellner   +5 more
wiley   +1 more source

The rain feels different under the same umbrella: Experiences with poverty across LGBTQ subgroups

American Journal of Community Psychology, EarlyView.
Abstract Population‐based survey data have demonstrated that LGBTQ communities report varying rates of economic insecurity, yet very little research directly assesses how pathways into and experiences with poverty look different among subgroups at the intersections of sexual orientation and gender identity (SOGI).
Bianca D. M. Wilson, Lillian Nguyen
wiley   +1 more source