Results 1 to 10 of about 8,589 (193)

Alterations in the hepatic drug-metabolizing enzyme network of mice induced by +Gz exposure and its impact on the pharmacokinetics and pharmacodynamics of modafinil [PDF]

Frontiers in Pharmacology
BackgroundIn aviation and aerospace missions, personnel and astronauts are subjected to brief episodes of +Gz acceleration, resulting in overload stress that adversely affects the cardiovascular, respiratory, and nervous systems.
Fengzhou Liu, Fengzhou Liu, Fengzhou Liu, Hui Shen, Qun Wan, Yajuan Li, Gang Zhao, Xiao Liu, Wei Lin, Junhui Xue, Junhui Xue, Junhui Xue   +11 more
doaj   +2 more sources

Modafinil-associated psychosis: a systematic review of case characteristics and management strategies [PDF]

Therapeutic Advances in Psychopharmacology
Background: Modafinil is a wakefulness-promoting agent widely used for narcolepsy and other sleep disorders. Although considered relatively safe, psychotic episodes associated with its use have been reported.
Yutaro Sato, Atsushi Sakuma, Hiroaki Tomita   +2 more
doaj   +2 more sources

Dyskinesia following modafinil administration in a patient with autism spectrum disorder and narcolepsy: a case report [PDF]

Journal of Medical Case Reports
Background In our clinical practice, we encountered a patient with autism spectrum disorder (ASD) and comorbid narcolepsy who developed dyskinesia following the administration of modafinil for excessive daytime sleepiness.
Kuniyuki Niijima, Kazuhiko Kume, Naoki Murabayashi, Masakazu Wakai   +3 more
doaj   +2 more sources

Stable interindividual differences in modafinil’s effect on vigilance during sleep deprivation [PDF]

Frontiers in Pharmacology
RationaleIn specific operational contexts (i.e., military aviation), the off-label use of modafinil is officially regulated. However, safety concerns are still raised.ObjectivesTo study the stability and robustness of interindividual differences in ...
Jeroen Van Cutsem, Jeroen Van Cutsem, Martine Van Puyvelde, Martine Van Puyvelde, Martine Van Puyvelde, Nicholas H. Van den Berg, Nicholas H. Van den Berg, Emilie Dessy, Frederic Detaille, Frederic Detaille, An Van Rompay, Olivier Mairesse, Olivier Mairesse, Catherine Drogou, Catherine Drogou, Fabien Sauvet, Fabien Sauvet, Xavier Neyt, Nathalie Pattyn, Nathalie Pattyn, Nathalie Pattyn, Nathalie Pattyn, Guido Simonelli, Guido Simonelli, Guido Simonelli   +24 more
doaj   +2 more sources

Late onset mania possibly related to modafinil use: a case report

Psychiatry and Clinical Psychopharmacology, 2021
Modafinil is used in the treatment of excessive day time sleepiness associated with several clinical conditions. Adjunctive modafinil therapy has also been suggested to improve residual symptoms such as fatigue and sleepiness in unipolar and bipolar ...
Meltem Gullu Kanal, Cetin Ozkan, Ozge Doganavsargil, Mehmet Eryılmaz   +3 more
doaj   +1 more source

Combined electrochemistry and mass spectrometry imaging to interrogate the mechanism of action of modafinil, a cognition-enhancing drug, at the cellular and sub-cellular level

QRB Discovery, 2021
Modafinil is a mild psychostimulant-like drug enhancing wakefulness, improving attention and developing performance in various cognitive tasks, but its mechanism of action is not completely understood.
Elias Ranjbari, Mai H. Philipsen, Zhaoying Wang, Andrew G. Ewing   +3 more
doaj   +1 more source

Modafinil increases the latency of response in the Hayling Sentence Completion Test in healthy volunteers: a randomised controlled trial. [PDF]

PLoS ONE, 2014
Modafinil is a medication licensed for the treatment of narcolepsy. However, it has been reported that healthy individuals without wakefulness disorders are using modafinil off-label to enhance cognitive functioning.
Ahmed Dahir Mohamed, Chris Roberts Lewis
doaj   +1 more source

Modafinil. Armodafinil. The use of eugeroics in assisting the treatment of depression, bipolar disorder, and schizophrenia. Benefits, drawbacks, and adverse effects

Journal of Education, Health and Sport, 2023
Modafinil is used to treat narcolepsy with cataplexy and is also being extensively studied to find new therapeutic uses. In recent years, there have been reports suggesting the potential benefits of modafinil in the treatment of psychiatric illnesses ...
Norbert Kandefer, Anna Jaremek, Joanna Kępa, Michał Wyszkowski, Aleksandra Grabarczyk, Anna Pawlak, Sylwia Grad, Paweł Gregorek, Małgorzata Gregorek, Laura Loryś, Klaudia Klimczak   +10 more
doaj   +1 more source

The off-prescription use of modafinil: An online survey of perceived risks and benefits.

PLoS ONE, 2020
Cognitive enhancing drugs are claimed to improve cognitive functions such as learning and attention. However, little is known presently about the characteristics of off-prescription cognitive enhancing drug users or their perceived everyday experience ...
Rachel D Teodorini, Nicola Rycroft, James H Smith-Spark   +2 more
doaj   +1 more source

Modafinil Reduces Neuronal Pyroptosis and Cognitive Decline After Sleep Deprivation

Frontiers in Neuroscience, 2022
Sleep deprivation (SD) induces systemic inflammation that promotes neuronal pyroptosis. The purpose of this study was to investigate the effect of an antioxidant modafinil on neuronal pyroptosis and cognitive decline following SD.
Xiangyang Xiong, Yan Zuo, Lu Cheng, Zhenyu Yin, Tianpeng Hu, Mengtian Guo, Zhaoli Han, Xintong Ge, Wenzhu Li, Yan Wang, Dong Wang, Conglin Wang, Lan Zhang, Yaodan Zhang, Qiang Liu, Fanglian Chen, Ping Lei   +16 more
doaj   +1 more source