Results 21 to 30 of about 6,043 (157)
Frontiers in Pharmacology, 2019 Studies on the abuse potential of modafinil, a psychostimulant-like drug used to treat narcolepsy, are still controversial. While some studies claim no potential for abuse, increasing evidence suggests that modafinil induces abuse-related effects ...
Raphael Wuo-Silva +12 more
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The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. [PDF]
PLoS ONE, 2011 Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction.
Kyle C Schmitt, Maarten E A Reith
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Modafinil as a catecholaminergic agent: empirical evidence and unanswered questions
Frontiers in Neurology, 2013 Modafinil, in its two clinical formulations (Provigil® and Nuvigil®), is a widely prescribed wake-promoting therapeutic agent. It binds competitively to the cell membrane dopamine transporter and is dependent on catecholaminergic (dopaminergic ...
Jonathan P Wisor
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Journal of Pharmacy & Pharmaceutical Sciences, 2010 Purpose. The pharmacokinetics of modafinil were investigated in relation to gender and ethnicity in healthy young volunteers from Han, Mongolian, Korean, Uygur and Hui ( n = 10/group) following administration of a single 200 mg oral dose. Methods.
Tao Guo, Longshan Zhao, Dong-Ya Xia
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The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. [PDF]
PLoS ONE, 2012 BACKGROUND: We have previously shown that modafinil promotes wakefulness via dopamine receptor D(1) and D(2) receptors; however, the locus where dopamine acts has not been identified. We proposed that the nucleus accumbens (NAc) that receives the ventral
Mei-Hong Qiu +5 more
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Modafinil Induced Psychosis in a Patient with Bipolar 1 Depression
Case Reports in Psychiatry, 2018 Modafinil has been used as an adjunctive medication in the treatment of bipolar 1 depression with reported success. Case reports have been published demonstrating modafinil induced mania in bipolar patients and modafinil induced psychosis in ...
Alexander A. DiSciullo +2 more
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Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. [PDF]
PLoS ONE, 2012 Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine ...
Mariana Raineri +7 more
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Modafinil does not reduce cocaine use in methadone-maintained individuals
Drug and Alcohol Dependence Reports, 2022 Introduction: There are no approved medications for the treatment of cocaine use disorder (CUD). Modafinil, a cognitive-enhancer with weak stimulant-like effects, has shown promise in initial studies as a treatment for CUD. Its potential efficacy has not
Elise E. DeVito +5 more
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Journal of Applied Toxicology, EarlyView.ABSTRACT Modafinil (2‐(benzhydrylsulfinyl)acetamide) is a psychostimulant commonly prescribed for sleep disorders such as narcolepsy, excessive daytime sleepiness, and obstructive sleep apnea. Recently, its use has extended beyond clinical indications, with neurotypical individuals adopting it as a smart drug to enhance alertness and cognitive ...
Luciane Dellazari da Silva do Prado +9 more
wiley +1 more source
Comparison of modafinil and pitolisant in narcolepsy: a non-inferiority metaanalytical approach
Drugs in Context, 2020 Aim: To assess the non-inferiority of pitolisant, a new compound for the relief of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy, compared with modafinil.
Philippe Lehert, Cassandra Szoeke
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