The atypical stimulant and nootropic modafinil interacts with the dopamine transporter in a different manner than classical cocaine-like inhibitors. [PDF]
PLoS ONE, 2011 Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction.
Kyle C Schmitt, Maarten E A Reith
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2010 Purpose. The pharmacokinetics of modafinil were investigated in relation to gender and ethnicity in healthy young volunteers from Han, Mongolian, Korean, Uygur and Hui ( n = 10/group) following administration of a single 200 mg oral dose. Methods.
Tao Guo, Longshan Zhao, Dong-Ya Xia
doaj +1 more source
The role of nucleus accumbens core/shell in sleep-wake regulation and their involvement in modafinil-induced arousal. [PDF]
PLoS ONE, 2012 BACKGROUND: We have previously shown that modafinil promotes wakefulness via dopamine receptor D(1) and D(2) receptors; however, the locus where dopamine acts has not been identified. We proposed that the nucleus accumbens (NAc) that receives the ventral
Mei-Hong Qiu +5 more
doaj +1 more source
Modafinil abrogates methamphetamine-induced neuroinflammation and apoptotic effects in the mouse striatum. [PDF]
PLoS ONE, 2012 Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine ...
Mariana Raineri +7 more
doaj +1 more source
Modafinil improves monocrotaline-induced pulmonary hypertension rat model
, 2020 BACKGROUND: Pulmonary arterial hypertension (PAH) progressively leads to increases in pulmonary vasoconstriction. Modafinil plays a role in vasorelaxation and blocking KCa3.1 channel with a result of elevating intracellular cyclic adenosine monophosphate
조민선 +3 more
core +1 more source
Modafinil does not reduce cocaine use in methadone-maintained individuals
Drug and Alcohol Dependence Reports, 2022 Introduction: There are no approved medications for the treatment of cocaine use disorder (CUD). Modafinil, a cognitive-enhancer with weak stimulant-like effects, has shown promise in initial studies as a treatment for CUD. Its potential efficacy has not
Elise E. DeVito +5 more
doaj +1 more source
A real‐world analysis of AI chatbot performance for medicines information enquiries
Journal of Pharmacy Practice and Research, EarlyView.Abstract Background The provision of medicines information (MI) services requires interpretation and clinical judgement of complex scenarios by pharmacists. To date, few studies have assessed the performance of artificial intelligence (AI) chatbots to assist pharmacists providing MI advice.
Duncan Yorkston +2 more
wiley +1 more source
Modafinil: A smart drug with psychiatric implications
, 2017 IntroductionModafinil is approved to treat excessive somnolence but it is also off-spec used as a treatment for ADHD and as a cognitive enhancer. Research on the effects of modafinil on cognitive function have yielded mixed results.
L. Montes Reula +7 more
core +1 more source
Comparison of modafinil and pitolisant in narcolepsy: a non-inferiority metaanalytical approach
Drugs in Context, 2020 Aim: To assess the non-inferiority of pitolisant, a new compound for the relief of excessive daytime sleepiness (EDS) and cataplexy in narcolepsy, compared with modafinil.
Philippe Lehert, Cassandra Szoeke
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source