Results 191 to 200 of about 6,861,462 (220)

Oseltamivir drug‐disease modelling in infants with influenza virus infection

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Oseltamivir is a commonly used neuraminidase inhibitor for treatment of influenza infection, but little data exist regarding concentration‐response relationships. Methods Pharmacokinetic (PK) and viral dynamic data from an earlier NIAID Collaborative Antiviral Study Group trial in paediatric patients with influenza from 0–23 months of age
Kun Wang, David W. Kimberlin, Richard J. Whitley, Edward P. Acosta, For the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group   +4 more
wiley   +1 more source

Young children's right to be heard on the quality of their education: Addressing potential misunderstandings in the context of early childhood education

British Educational Research Journal, EarlyView.
Abstract In early childhood education many researchers and professionals across the world have embraced the United Nations Convention on the Rights of the Child's requirement to include young children in decision‐making. In the context of ongoing discussion about young children's capacity to share their views and opinions about matters affecting them ...
Laura Lundy, Colette Murray, Kylie Smith, Carmel Ward   +3 more
wiley   +1 more source

Career motivations and perceptions of teaching of 16–19‐year‐olds in England and Wales

British Educational Research Journal, EarlyView.
Abstract The current study provides an understanding of career‐related motivations of 16–19‐year‐olds in schools and A‐level colleges in England and Wales. The 672 participants (62% women) were asked to complete a modified version of the Motivations for Career Choice and the Persistence Research in Science and Engineering scales and provide comments on
Sophie Thompson‐Lee, Rebecca, J. S. Snell, Hui Wang, Robert M. Klassen   +4 more
wiley   +1 more source

Understanding exam access arrangements in practice: Challenges and opportunities

British Educational Research Journal, EarlyView.
Abstract Secondary students with specific learning difficulties (SpLD) often face challenges with academic tasks, particularly with high‐stakes examinations. Exam access arrangements (EAA) are provided as reasonable adjustments to reduce disadvantage for students with SpLD.
Catherine Antalek, Amelia Roberts, Emma Sumner   +2 more
wiley   +1 more source

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Subchronic PCP effects on DNA methylation and protein expression of NMDA receptor subunit genes in the prefrontal cortex and hippocampus of female rats

Journal of Psychopharmacology, 2022
Background: N-methyl-d-aspartate receptor (NMDAR) dysfunction is implicated in schizophrenia, and NMDAR antagonists, such as phencyclidine (PCP), can induce behaviours that mimic aspects of the disorder. Aims: We investigated DNA ...
Camila M Loureiro, Helene A Fachim, Michael K Harte, Caroline F Dalton, Gavin P Reynolds   +4 more
openaire   +3 more sources

Quantitative study of the PCP effect

Chemical Physics Letters, 2009
Abstract Recent studies of the π -electron properties of acenaphthylene, fluoranthene, and their congeners showed that the presence of phenyl–cyclopentadienyl (PCP) fragments amplifies the intensity of cyclic conjugation in the five-membered ring of the respective molecules.
Slavko Radenković, Jelena Đurđević, Ivan Gutman   +2 more
openaire   +1 more source

Phencyclidine (PCP): Effects on limbic afterdischarges in the rhesus monkey

Brain Research Bulletin, 1984
Effects of phencyclidine (PCP) on eliciting afterdischarges (AD) by electrical stimulation of the hippocampus (HIPP), amygdala (AMY), thalamus (CM) and midbrain reticular formation (MRF) were studied in rhesus monkeys with permanently implanted encephalic electrodes.
M, Matsuzaki, K C, Dowling
openaire   +2 more sources

Phencyclidine (PCP): Effects on auditory evoked potentials in the rhesus monkey

Brain Research Bulletin, 1984
Effects of acute and chronic administration of phencyclidine (PCP) on auditory evoked potentials (AEPs) were studied in rhesus monkeys with encephalic electrodes permanently implanted. AEPs were evoked by single clicks (1.0 pps in frequency) generated by an externally triggered audiomonitor.
M, Matsuzaki, K C, Dowling
openaire   +2 more sources

Phencyclidine (PCP): Effects of acute and chronic administration on egg activities in the rhesus monkey

Electroencephalography and Clinical Neurophysiology, 1985
Effects of acute and chronic administration of phencyclidine (PCP) on EEG activities and gross behavior were studied in monkeys with electrodes implanted in the brain. Administration of PCP (2.0 or 4.0 mg/kg i.v.) in monkeys produced a biphasic pattern of inhibition and excitation of behavior during 6-8 h observation period.
M, Matsuzaki, K C, Dowling
openaire   +2 more sources

The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity

Neuropharmacology, 2002
Phencyclidine (PCP), a non-competitive antagonist of ionotropic N-methyl-D-aspartate (NMDA) receptors, produces psychotomimetic effects, such as a disruption in prepulse inhibition (PPI) of the startle response. NMDA antagonists also induce locomotor hyperactivity in rodents.
S A, Henry, V, Lehmann-Masten, F, Gasparini, M A, Geyer, A, Markou   +4 more
openaire   +2 more sources