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The Multifaceted Biology of PCSK9 [PDF]
Endocrine Reviews, 2021 This article reviews the discovery of PCSK9, its structure–function characteristics, and its presently known and proposed novel biological functions.
N. Seidah, A. Prat
semanticscholar +4 more sources
Plasma PCSK9 preferentially reduces liver LDL receptors in mice* [PDF]
Journal of Lipid Research, 2008 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower ...
Aldo Grefhorst +3 more
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Journal of Experimental & Clinical Cancer Research, 2022 Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 expression was reportedly associated with tumor development and progression.
Lu Wang +4 more
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PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation [PDF]
Mediators of Inflammation, 2020 Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced.
Elena Dozio +7 more
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Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice [PDF]
Frontiers in PharmacologyInstructionAccumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear.
Xue-Ying Zhang +6 more
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Journal of Lipid Research, 2012 PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor.
Gilles Lambert +4 more
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Plasma PCSK9 levels are significantly modified by statins and fibrates in humans [PDF]
Lipids in Health and Disease, 2008 Background Proprotein convertase subtilisin kexin-like 9 (PCSK9) is a secreted glycoprotein that is transcriptionally regulated by cholesterol status. It modulates levels of circulating low density lipoprotein cholesterol (LDLC) by negatively regulating ...
Mbikay Majambu +9 more
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Insight into the Evolving Role of PCSK9
Metabolites, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells.
M. Maligłówka +9 more
semanticscholar +5 more sources
PCSK9 antagonists and inflammation [PDF]
Atherosclerosis, 2018 Corsini, Alberto +3 more
core +6 more sources
PCSK9 Gene Polymorphisms Associated With the Risk of Myocardial Infarction in Iranian Patients [PDF]
International Journal of Basic Science in Medicine, 2021 Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulatory protein in lipid metabolism and a candidate gene in the etiology of cardiovascular diseases.
Farshad Namordizadeh, Mahboobeh Nasiri
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