Results 31 to 40 of about 19,854 (197)
Arthritis Research & Therapy, 2021 Background Proprotein convertase subtilisin kexin 9 (PCSK9) targets the LDL-receptor (LDLR) which raises LDL-levels. In addition, PCSK9 has proinflammatory immunological effects.
Johan Frostegård +4 more
doaj +1 more source
American Journal of Medicine Open, 2023 Background: Real-world data on use of PCSK9 inhibitors (PCSK9-Is), with or without statins and/or ezetimibe, and associated outcomes, can inform more effective prescribing.
Jessica Eloso +8 more
doaj +1 more source
PCSK9 function and physiology [PDF]
Journal of Lipid Research, 2008 PCSK9 has exploded onto center stage plasma cholesterol metabolism, raising hopes for a new strategy to treat hypercholesterolemia. PCSK9 in a plasma protein that triggers increased degradation of the LDL receptor. Gain-of-function mutations in PCSK9 reduce LDL receptor levels in the liver, resulting in high levels of LDL cholesterol in the plasma and ...
Andrew S, Peterson +2 more
openaire +3 more sources
PCSK9 inhibitors for hypercholesterolaemia [PDF]
BMJ, 2017 New drugs, old problems Statins (hydroxymethyl-glutaryl coenzyme A reductase inhibitors) reduce “bad” low density lipoprotein (LDL) cholesterol concentrations and cardiovascular risk. So too, do better diet and more exercise, which together almost halve rates of coronary event rates when compared with an “unfavourable lifestyle.”3 For some people ...
Patricia, McGettigan, Robin E, Ferner
openaire +2 more sources
Insight into the Evolving Role of PCSK9
Metabolites, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the last discovered member of the family of proprotein convertases (PCs), mainly synthetized in hepatic cells. This serine protease plays a pivotal role in the reduction of the number of low-density lipoprotein receptors (LDLRs) on the surface of hepatocytes, which leads to an increase in the ...
Mateusz Maligłówka +9 more
openaire +4 more sources
The Role of PCSK9 in Infectious Diseases
Current Medicinal Chemistry, 2022 Background: In recent years, many aspects of the physiological role of PCSK9 have been elucidated, in particular regarding its role in lipid metabolism, cardiovascular risk but also its role in innate immunity. Increasing evidence is available on the involvement of PCSK9 in the pathogenesis of viral infections, mainly HCV, as well as in the regulation
Magnasco, Laura +7 more
openaire +3 more sources
Frontiers in Oncology, 2021 BackgroundEsophageal cancer often appears as postoperative metastasis or recurrence after radical surgery. Although we had previously reported that serum programmed cell death ligand 1 (PD-L1) level correlated with the prognosis of esophageal cancer ...
Masaaki Ito +19 more
doaj +1 more source
BMC Emergency Medicine, 2023 Objectives Pro-protein convertase subtilisin/kexin 9 (PCSK9) decreases the clearance of the pathogenic lipids, supporting the potential role of PCSK9 in the prognosis of sepsis.
Yuanlu Shu +9 more
doaj +1 more source
Renal Failure, 2023 Purpose The purpose of this study was to investigate the association between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and renal function impairment in type 2 diabetes mellitus (T2DM) patients.Methods PCSK9 levels were measured ...
Zhicai Feng +5 more
doaj +1 more source
PCSK9: A Key Target for the Treatment of Cardiovascular Disease (CVD) [PDF]
Advanced Pharmaceutical Bulletin, 2020 Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a vital modulator of low-density lipoprotein cholesterol (LDL-C) , is raised in hepatocytes and released into plasma where it binds to LDL receptors (LDLR), leading to their cleavage.
Saeideh Sobati +6 more
doaj +1 more source