Results 51 to 60 of about 19,854 (197)

Prime editing in neuropsychiatric disorders: From mutation‐specific target selection to clinical translation

Neuroprotection, EarlyView.
Abstract Prime editing, a novel clustered regularly interspaced short palindromic repeats (CRISPR)‐based technology, fuses a reverse transcriptase (RT) to an engineered CRISPR‐associated protein 9 (Cas9) and uses a prime editing guide RNA (pegRNA)‐encoded template.
Tianshan Ji, Yuan Zhang, Jinyi Zhao, Yiping Lu, Chengkun Wang   +4 more
wiley   +1 more source

Therapeutic Gene Editing in Dyslipidemias

Reviews in Cardiovascular Medicine
Dyslipidemia, characterized by abnormal lipid levels in the blood, significantly escalates the risk of atherosclerotic cardiovascular disease and requires effective treatment strategies.
Seyed Saeed Tamehri Zadeh, Michael D. Shapiro   +1 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

PCSK9: Is it Fluoride for Cardiology?

JACC: Cardiovascular Interventions, 2014
![Figure][1] When I first came to Emory in the 1960s, we had a medical school and a dental school. Now there is just the medical school. What happened to the dental school? The Emory Dental School, along with several others across the country, closed because of a reduced demand for dentists.
openaire   +2 more sources

PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation

Mediators of Inflammation, 2020
Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced.
Elena Dozio, Massimiliano Ruscica, Elena Vianello, Chiara Macchi, Clementina Sitzia, Gerd Schmitz, Lorenza Tacchini, Massimiliano M. Corsi Romanelli   +7 more
doaj   +1 more source

Prevention of Triglyceridemia by (Non-)Anticoagulant Heparin(oids) Does Not Preclude Transplant Vasculopathy and Glomerulosclerosis

Frontiers in Cell and Developmental Biology, 2022
Background: In renal transplantation, chronic transplant dysfunction (CTD) is associated with increased PCSK9 and dyslipidemia. PCSK9 is an enzyme that increases plasma cholesterol levels by downregulating LDLR expression.
Pragyi Shrestha, Kirankumar Katta, Ditmer Talsma, Annamaria Naggi, Jan-Luuk Hillebrands, Bart van de Sluis, Jacob van den Born   +6 more
doaj   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

British Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Regulation of PCSK9 by nutraceuticals

Pharmacological Research, 2017
PCSK9 (proprotein convertase subtilisin kexin type 9) is a liver secretory enzyme that regulates plasma low-density lipoprotein (LDL) cholesterol (LDL-C) levels through modulation of LDL receptor (LDLR) density on the surface of hepatocytes. Inhibition of PCSK9 using monoclonal antibodies can efficiently lower plasma LDL-C, non-high-density lipoprotein
Amir Abbas, Momtazi, Maciej, Banach, Matteo, Pirro, Niki, Katsiki, Amirhossein, Sahebkar   +4 more
openaire   +2 more sources

Relationship of sortilin and proprotein convertase subtilisin/kexin type 9 in blood serum with the severity of carotid and coronary atherosclerosis in hypertensive patients

Российский кардиологический журнал, 2022
Sortilin is an important molecular protein involved in lipid metabolism, atherosclerosis,  and aortic valve calcification. Sortilin presumably regulates the PCSK9 signaling pathways.Aim.
Yu. Yu. Vukolova, I. V. Gubareva
doaj   +1 more source

Multivalent antibody‐based conjugates as new tools for tailored modulation of G protein–coupled receptors

British Journal of Pharmacology, EarlyView.
The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley   +1 more source