Results 71 to 80 of about 28,066 (219)

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Pleiotropy of PCSK9: Functions in Extrahepatic Tissues

, 2023
Purpose of Review: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a central role in the metabolism of LDL receptors and mainly acts in the liver.
Şener, Yusuf Ziya, Tokgözoğlu, Lale, Lale Tokgözoğlu, Yusuf Ziya Şener   +3 more
core   +1 more source

PCSK9 Expression in Epicardial Adipose Tissue: Molecular Association with Local Tissue Inflammation

Mediators of Inflammation, 2020
Epicardial adipose tissue (EAT) has the unique property to release mediators that nourish the heart in healthy conditions, an effect that becomes detrimental when volume expands and proinflammatory cytokines start to be produced.
Elena Dozio, Massimiliano Ruscica, Elena Vianello, Chiara Macchi, Clementina Sitzia, Gerd Schmitz, Lorenza Tacchini, Massimiliano M. Corsi Romanelli   +7 more
doaj   +1 more source

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Animal Models and Experimental Medicine, EarlyView.
Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou, Xue Liu, Wangxing Hu, Xianbao Liu, Wei Zhu   +4 more
wiley   +1 more source

Plasma PCSK9 preferentially reduces liver LDL receptors in mice*

Journal of Lipid Research, 2008
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein that regulates the expression of LDL receptor (LDLR) protein. Gain-of-function mutations in PCSK9 cause hypercholesterolemia, and loss-of-function mutations result in lower ...
Aldo Grefhorst, Markey C. McNutt, Thomas A. Lagace, Jay D. Horton   +3 more
doaj   +1 more source

การออกแบบและสังเคราะห์อนุพันธ์เบอร์เบอรีนให้เป็นตัวยับยั้ง PCSK9 เพื่อลดระดับไขมัน [PDF]

, 2021
Nowadays, Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) has become a new target for hypercholesterolemia treatment. PCSK9 is a crucial protein in Low-Density Lipoprotein cholesterol (LDL-C) metabolism by regulating the degradation of hepatic low ...

core  

PCSK9 Inhibitors in the Management of Cardiovascular Risk: A Practical Guidance

, 2022
Xiaoming Jia,1 Mahmoud Al Rifai,1 Anum Saeed,2 Christie M Ballantyne,1 Salim S Virani1,3 1Department of Medicine, Baylor College of Medicine, Houston, TX, USA; 2Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA ...
Virani SS, Ballantyne CM, Jia X, Al Rifai M, Saeed A   +4 more
core  

Beyond LDL: What Role for PCSK9 in Triglyceride-Rich Lipoprotein Metabolism?

, 2018
International audienceElevated plasma triglyceride (TG) levels are an independent risk factor for cardiovascular disease (CVD). Proprotein convertase subtilisin-kexin 9 (PCSK9) - a protein therapeutically targeted to lower plasma cholesterol levels ...
Cédric Le May, Cariou, Bertrand, Bertrand Cariou, Le May, Cedric, Wieneke Dijk, Dijk, Wieneke   +5 more
core   +1 more source

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞

Journal of Lipid Research, 2008
Mutations within proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with dominant forms of familial hypercholesterolemia. PCSK9 binds the LDL receptor (LDLR), and addition of PCSK9 to cells promotes degradation of LDLR.
Shilpa Pandit, Doug Wisniewski, Joseph C. Santoro, Sookhee Ha, Vijayalakshmi Ramakrishnan, Rose M. Cubbon, Richard T. Cummings, Samuel D. Wright, Carl P. Sparrow, Ayesha Sitlani, Timothy S. Fisher   +10 more
doaj   +1 more source