Results 1 to 10 of about 37,789 (262)

PCSK9 and LDL-C: The Role of Exercise [PDF]

운동과학, 2020
s Purpose Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) is a pivotal regulator of low lipoprotein-cholesterol (LDL-C) and LDL receptor (LDLR) metabolism, and the interest in PCSK9 has increased in cardiovascular diseases.
Jaeho Jin, Wooyeon Jo, Ji Heon Noh, Sang Ki Lee   +3 more
doaj   +1 more source

Tính chất đột biến gene APOB và LDLR trên bệnh tăng cholesterol máu ở người Việt Nam

Tạp chí Khoa học Đại học Mở Thành phố Hồ Chí Minh - Kỹ thuật và Công nghệ, 2022
Bệnh lý rối loạn tăng cholesterol máu ở dạng có tính chất gia đình (FH) với nguyên nhân là sự xuất hiện đột biến tác động đến chức năng của gene APOB và LDLR.
Trương Kim Phượng, Đỗ Nguyễn Mai Thy, Nguyễn Bảo Toàn, Lê Huyền Ái Thúy   +3 more
doaj   +1 more source

The effect of PCSK9 immunization on the hepatic level of microRNAs associated with PCSK9/LDLR pathway.

Archives of Medical Science, 2023
Introduction MicroRNAs (miRNAs) are a class of gene expression epigenetic regulators that play roles in regulating genes involved in cholesterol homeostasis, including low-density lipoprotein receptor (LDLR) and PCSK9; therefore, miRNAs have been ...
Sarina Ataei, Shiva Ganjali, Maciej Banach, Ehsan Karimi, Amirhossein Sahebkar   +4 more
doaj   +1 more source

Anti-inflammatory effect of ApoE23 on Salmonella typhimurium-induced sepsis in mice

Open Medicine, 2023
Two independent experiments were performed with three groups each (sepsis control, sepsis, and sepsis with apoE23 treatment) to investigate the anti-inflammatory effect of apolipoprotein 23 (apoE23) in a mouse model of sepsis induced by S.
Wang Chuanqing, Yin Lijun, Fu Pan, Lu Guoping, Zhai Xiaowen, Yang Changsheng   +5 more
doaj   +1 more source

PCSK9 Relationship with LDL and LDLR: A Promising Method for Treatment of Dyslipidemia [PDF]

المجلة العراقية للصيدلة
Background: One of the most significant risk factors for cardiovascular (CV) disease is dyslipidemia, exacerbated atherosclerosis, and premature mortality due to heart attack.
Nour Alhafidh, Musab Khalaf, Nashaat Mustafa   +2 more
doaj   +1 more source

Comparison between genetic and pharmaceutical disruption of Ldlr expression for the development of atherosclerosis

Journal of Lipid Research, 2022
Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies.
Diego Gomes, Shari Wang, Leela Goodspeed, Katherine E. Turk, Tomasz Wietecha, Yongjun Liu, Karin E. Bornfeldt, Kevin D. O'Brien, Alan Chait, Laura J. den Hartigh   +9 more
doaj   +1 more source

Low Density Lipoprotein Receptor (LDLR) and 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase (HMGCR) Expression are Associated with Platinum-Resistance and Prognosis in Ovarian Carcinoma Patients

Cancer Management and Research, 2021
Xueyao Huang,1,2 Xuan Wei,1 Sijing Qiao,1,2 Xue Zhang,1,2 Rui Li,1 Shunxue Hu,3 Hongluan Mao,1,2 Peishu Liu1,2 1Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People’s Republic of China; 2Shandong ...
Huang X, Wei X, Qiao S, Zhang X, Li R, Hu S, Mao H, Liu P   +7 more
doaj  

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice

PLoS ONE, 2021
Background and aims Diabetes is a major risk factor of atherosclerosis and its complications. The loss-of-function mutation E1506K in the sulfonylurea receptor 1 (SUR1-E1506K) induces hyperinsulinemia in infancy, leading to impaired glucose tolerance and
Erika Gurzeler, Anna-Kaisa Ruotsalainen, Anssi Laine, Teemu Valkama, Sanna Kettunen, Markku Laakso, Seppo Ylä-Herttuala   +6 more
doaj   +2 more sources

Increased LDL receptor by SREBP2 or SREBP2-induced lncRNA LDLR-AS promotes triglyceride accumulation in fish

iScience, 2022
Summary: LDLR, as the uptake receptor of low-density lipoprotein, plays a crucial role in lipid metabolism. However, the detailed mechanism by which LDLR affects hepatic triglyceride (TG) accumulation has rarely been reported.
Xiufei Cao, Wei Fang, Xueshan Li, Xiuneng Wang, Kangsen Mai, Qinghui Ai   +5 more
doaj   +1 more source

GENETIC VARIATION OF cDNA OF LDLR GENE IN HYPORESPONDER CYNOMOLGUS MACAQUES (Macaca fascicularis)

Jurnal Kedokteran Hewan, 2017
The study aimed to identify genetic variation of cDNA sequence from low density lipoprotein receptor (LDLR) gene of hyporesponder cynomolgus macaques. The animal used in this study was one hyporesponder cynomolgus macaque obtained from selection result ...
Achmad Taher, Dedy Duryadi Solihin, Sulistiyani Sulistiyani, Dondin Sajuthi, Dewi Apri Astuti   +4 more
doaj   +1 more source