Results 31 to 40 of about 37,789 (262)
LDLR-dependent distribution of Fc-conjugates in mice organs.
, 2018 (A) Anti-hFc Western Blot analysis of 100 μg of liver and 35 μg of adrenal gland lysates from WT mice injected i.v. with PBS (mouse m1), with the (VH4127)2-Fc conjugate (mice m2, m4, m6), and with the (VH4Sc)2-Fc conjugate (mice m3, m5, m7).
Nicolas Gaudin (3206940) +11 more
core +1 more source
Therapeutic Immune Reprogramming by Rapamycin Attenuates Plaque Inflammation and Lymphoid Immune Responses in Aged Atherosclerotic Mice. [PDF]
Aging CellRapamycin exerts multifaceted immunomodulatory effects in age‐induced atherosclerosis, with pronounced inhibitory effects on adaptive immunity. Rapamycin reduced plaque inflammation and macrophage content, diminished pro‐inflammatory T cell responses, lowered age‐associated B cell frequencies, and attenuated senescence‐associated immune signatures ...
de Mol J +9 more
europepmc +2 more sources
Molecular and biochemical characterization of LDLR+/+, LDLR+/−, and LDLR−/− pigs.
, 2014 A. Genotyping by PCR. Expected sizes are 1.5-type LDLR and 3.2 kb for targeted LDLR. B. Southern blot of genomic DNA. (Left) XmnI digested genomic DNA was hybridized with a probe that detects porcine LDLR downstream of the targeting vector boundary.
Christopher S. Rogers (545570) +8 more
core +1 more source
Therapeutic Gene Editing in Dyslipidemias
Reviews in Cardiovascular MedicineDyslipidemia, characterized by abnormal lipid levels in the blood, significantly escalates the risk of atherosclerotic cardiovascular disease and requires effective treatment strategies.
Seyed Saeed Tamehri Zadeh +1 more
doaj +1 more source
Gene Expression of LDLR, APOB, APOE, and LPL in Experimentally Induced Diabetes and Dyslipidemia in Rats [PDF]
Iraqi Journal of Veterinary SciencesDiabetes is the predominant metabolic condition in humans and animals, particularly in pets; it frequently coexists with many other metabolic abnormalities involving carbohydrates, proteins, and lipids.
Harikar Mahmood, Nashaat Mustafa
doaj +1 more source
Frontiers in Genetics, 2021 We report a single-point variant of low-density lipoprotein receptor (LDLR) in a Chinese proband with a clinical diagnosis of familial hypercholesterolemia (FH) with a comprehensive functional analysis.
Hong-Yan Shu +5 more
doaj +1 more source
Clinical characteristics of LDLR-M and LDLR-WT groups.
, 2018 Clinical characteristics of LDLR-M and LDLR-WT groups.
Michał Studniarek (846526) +8 more
core +1 more source
LDLR-mediated lipidome-transcriptome reprogramming in cisplatin insensitivity [PDF]
Endocrine Abstracts, 2020 Platinum-based therapy remains the cornerstone for cancer therapy; however, its efficacy varies. The role of lipoprotein receptor-mediated lipid entry for cancer development has been reported. Yet, the roles and mechanism of the low-density lipoprotein receptor (LDLR) in chemo-sensitivities are unknown.
Wei-Chun, Chang +8 more
openaire +2 more sources
Neurobiology of Disease, 2004 The low-density lipoprotein receptor (LDLR) is the first described receptor for apolipoprotein E (apoE). We hypothesize that the absence of the LDLR, similar to the absence of apoE, results in impaired learning and memory processes.
Monique Mulder +8 more
doaj +1 more source
Lack of LDL receptor enhances amyloid deposition and decreases glial response in an Alzheimer's disease mouse model. [PDF]
PLoS ONE, 2011 BACKGROUND: Apolipoprotein E (ApoE), a cholesterol carrier associated with atherosclerosis, is a major risk factor for Alzheimer's disease (AD). The low-density lipoprotein receptor (LDLR) regulates ApoE levels in the periphery and in the central nervous
Loukia Katsouri, Spiros Georgopoulos
doaj +1 more source