Results 51 to 60 of about 37,789 (262)

Gut microbiota dysbiosis augments atherosclerosis in LDLR-/- mice [PDF]

, 2017
Aim: In recent years the gut microbiome has been recognized as an important participant in the etiology of obesity and -associated comorbidities. Moreover, recent studies have implicated an involvement of the gut microbiota in both cardiovascular health ...
Niels Kloosterhuis, Gijbels, Marion, Kloosterhuis, Niels J, Marion Gijbels, Dekker, Daphne C, Van Der Velden, Saskia, Menno de Winther, Hofker, Marten H, Koster, Miriam, de Bruin, Alain, Saskia Van Der Velden, Debby Koonen, Koonen, Debby P Y, Daphne Dekker, Brandsma, Eelke, Miriam Koster, Marten Hofker, de Winther, Menno, Eelke Brandsma, Marit Westerterp, Westerterp, Marit, van de Sluis, Bart, Alain de Bruin, Bart Van De Sluis   +23 more
core   +1 more source

Binding characteristics of a panel of monoclonal antibodies against the ligand binding domain of the human LDLr

Journal of Lipid Research, 2006
To obtain a panel of monoclonal antibodies (MAbs) to study the folding and conformation of the low density lipoprotein receptor (LDLr), we have generated hybridomas from LDLr-deficient mice that had been immunized with the extracellular domain of the ...
Anh T. Nguyen, Tomoko Hirama, Vinita Chauhan, Roger MacKenzie, Ross Milne   +4 more
doaj   +1 more source

Patients With LDLR and PCSK9 Gene Variants Experienced Higher Incidence of Cardiovascular Outcomes in Heterozygous Familial Hypercholesterolemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Patients with familial hypercholesterolemia who harbored both low‐density lipoprotein receptor (LDLR) and PCSK9 (proprotein convertase subtilisin/kexin type 9) gene variants exhibit severe phenotype associated with substantially high levels of
Takahito Doi, Mika Hori, Mariko Harada‐Shiba, Yu Kataoka, Daisuke Onozuka, Kunihiro Nishimura, Ryo Nishikawa, Kosuke Tsuda, Masatsune Ogura, Cheol Son, Yoshihiro Miyamoto, Teruo Noguchi, Hiroaki Shimokawa, Satoshi Yasuda   +13 more
doaj   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Expression of wt LDLr and p.(Cys46Gly) LDLr variant in CHO-ldlA7 transfected cells.

, 2018
Expression of LDLr was assessed 48 h post-transfection with the corresponding plasmids by A) Western blot, B) mature LDLr protein relative to GAPDH. LDLr expression of p.(Cys46Gly) LDLr variant determined by FACS with C) IgG-C7 antibody that recognizes ...
U. Galicia-Garcia (5866481), C. Martin (2339041), M. Stef (5866490), F. Civeira (5866496), K. B. Uribe (5866472), A. Larrea-Sebal (5866484), H. Ostolaza (5866493), H. Siddiqi (5866475), S. Jebari (5866478), A. Cenarro (5866487), A. Benito-Vicente (5866469), L. Palacios (5866499)   +11 more
core   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

A hipercolesterolemia e o envelhecimento como modulares do estresse oxidativo em modelo de hipercolesterolemia familiar [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Bioquímica, Florianópolis, 2013Por prover informações sobre o do funcionamento do metabolismo de seres vivos, antigas formações ...
Mancini, Gianni
core  

Calcium score distribution across AVCS in LDLR-M and LDLR-WT groups.

, 2018
Data in particular ranges are expressed as % of each calcium score subgroup. Abbreviations: LDLR-M–patients with familial hypercholesterolemia and LDLR mutation, LDLR-WT–nonfamilial hypercholesterolemia, AVCS—aortic valve calcium score.
Michał Studniarek (846526), Magdalena Chmara (3485393), Krzysztof Chlebus (6162953), Andrzej Rynkiewicz (6162956), Dorota Kulawiak-Gałąska (6162950), Marcin Gruchała (6162959), Rafal Gałąska (6162947), Bartosz Wasąg (804434), Marcin Fijałkowski (4568044)   +8 more
core   +1 more source

LDLR c.415G > A causes familial hypercholesterolemia by weakening LDLR binding to LDL

Lipids in Health and Disease
Abstract Background Familial hypercholesterolemia (FH) is a prevalent hereditary disease that can cause aberrant cholesterol metabolism. In this study, we confirmed that c.415G > A in low-density lipoprotein receptor ( LDLR ),
Kaihan Wang, Tingting Hu, Mengmeng Tai, Yan Shen, Haocheng Chai, Shaoyi Lin, Xiaomin Chen   +6 more
openaire   +3 more sources

From data to hypothesis: Exploring monocyte immunometabolism by principal component analysis of multiparametric flow cytometry

Acta Marisiensis - Seria Medica
Objective: Principal component analysis is a powerful dimensionality reduction tool that can uncover hidden patterns in complex biological data. In cellular immunology research, principal component analysis may help identify meaningful relationships ...
Mănescu Ion Bogdan, Gîrlea Daniel, Thomas Sara, Fotache Ana Maria, Demian Liliana   +4 more
doaj   +1 more source