Results 61 to 70 of about 37,789 (262)
Журнал микробиологии, эпидемиологии и иммунобиологииIntroduction. Hepatitis C virus (HCV) remains a significant public health concern. The application of existing antiviral agents is restricted by their high cost and the development of viral resistance, while vaccine development is impeded by the ...
Ekaterina V. Anufrieva +4 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
Inhibitors of AKT kinase increase LDL receptor mRNA expression by two different mechanisms.
PLoS ONE, 2019 Protein kinase B (AKT) is a serine/threonine kinase that functions as an important downstream effector of phosphoinositide 3-kinase. We have recently shown that MK-2206 and triciribine, two highly selective AKT inhibitors increase the level of low ...
Katrine Bjune +2 more
doaj +1 more source
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis
Journal of Lipid Research, 2007 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a protease that regulates low density lipoprotein receptor (LDLR) protein levels. The mechanisms of this action, however, remain to be defined.
Yue-Wei Qian +16 more
doaj +1 more source
Outgrowth of S. typhimurium in the organs of LDLR+/+ and LDLR−/− mice.
, 2013 Outgrowth of S. typhimurium in the liver, spleen and bone marrow of LDLR−/− and control (LDLR+/+) C57Bl/6J mice after i.v. injection of 102 cfu. Each point represents the mean±SD for at least 10 animals. Significant differences between LDLR−/− and LDLR+/+
Leo A. B. Joosten (195019) +6 more
core +1 more source
Therapeutic targets of hypercholesterolemia: HMGCR and LDLR.
Diabetes, metabolic syndrome and obesity : targets and therapy, 2019 Cholesterol homeostasis is critical and necessary for the body's functions. Hypercholesterolemia can lead to significant clinical problems, such as cardiovascular disease (CVD). 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) and low-density lipoprotein cholesterol receptor (LDLR) are major points of control in cholesterol homeostasis.
Ma,Shizhan +3 more
openaire +4 more sources
Interactions of NEU1 with ASGR and LDLR [PDF]
, 2019 Development of atherosclerosis, the hardening of the arteries, is dependent on levels of serum cholesterol, which is regulated by the liver via LDL receptors (LDLR). The expression and internalization of LDL receptors depend on several proteins including
Fisher, Kathryn
core +1 more source
Immunometabolic profiling of human monocytes in response to lipid exposure
Romanian Journal of Laboratory MedicineMonocytes are central in inflammation and atherogenesis. Postprandial lipemia is a known pro-atherogenic state, yet its impact on monocyte activation remains incompletely understood.
Mănescu Ion Bogdan +5 more
doaj +1 more source
International Journal of Cardiology: Heart & Vasculature, 2019 Background: IκBNS, a nuclear IκB protein, regulates a subset of Toll-like receptor (TLR) dependent genes. A cholate-containing high-fat diet (HFD(CA(+))) induces TLR4 mediated early inflammatory response.
Kenichi Kitamura +6 more
doaj +1 more source
Volumetric calcium score of aortic valve in LDLR-M and LDLR-WT groups.
, 2018 Volumetric calcium score of aortic valve in LDLR-M and LDLR-WT groups.
Michał Studniarek (846526) +8 more
core +1 more source