Results 71 to 80 of about 37,789 (262)

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Familial hypercholesterolemia in Tehran lipid and glucose study: A cross- sectional study

Payesh, 2016
bjective (s): Familial hypercholesterolemia (FH) is one of the most common hereditary disorders in lipid metabolism that is distinguished by high plasma concentrations of low-density lipoprotein cholesterol (LDL-C) and cholesterol, can be considered ...
Fatemeh Naghizadeh mooghari, Kamran Guity, Bahareh Sedaghatikhayat, Behzad Laamerad, Fereidoun Azizi, Maryam S Daneshpour, Maryam Daneshpour   +6 more
doaj  

Defects of the LDL receptor in WHHL transgenic rabbits lead to a marked accumulation of plasma lipoprotein[a]

Journal of Lipid Research, 2000
In this study, we created LDL receptor (LDLr) defective (WHHL) transgenic rabbits expressing human apo[a] to examine whether LDLr mediates the Lp[a] clearance from the plasma.
Jianglin Fan, Mireille Challah, Hiroaki Shimoyamada, Masashi Shiomi, Santica Marcovina, Teruo Watanabe   +5 more
doaj   +1 more source

Relationship between porcine miR-20a and its putative target low-density lipoprotein receptor based on dual luciferase reporter gene assays [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective Mutations in low-density lipoprotein receptor (LDLR), which encodes a critical protein for cholesterol homeostasis and lipid metabolism in mammals, are involved in cardiometabolic diseases, such as familial hypercholesterolemia in pigs. Whereas
Yueyun Ding, Shujiao Zhu, Chaodong Wu, Li Qian, DengTao Li, Li Wang, Yuanlang Wang, Wei Zhang, Min Yang, Jian Ding, Xudong Wu, Xiaodong Zhang, Yafei Gao, Zongjun Yin   +13 more
doaj   +1 more source

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Coronary artery atherosclerosis in 11-month-old LDLR−/−, LDLR +/−, and LDLR +/+ pigs fed a high fat, high cholesterol diet.

, 2014
Representative H&E stained sections from each group are shown: LDLR−/− (A,B), LDLR +/− (C,D), and LDLR +/+ (E,F). Complex lesions were seen in the LDLR−/− pigs (A,B) that exhibited hemorrhage, possible areas of calcification, fibrous caps and foam cells.
Christopher S. Rogers (545570), Jason T. Struzynski (545565), Frank A. Rohret (545568), Timothy C. Nichols (545569), Bryan T. Davis (545563), Elizabeth P. Merricks (545566), Judy A. Rohret (545564), Xiao-Jun Wang (321924), Dwight A. Bellinger (545567)   +8 more
core   +1 more source

In-vivo cytokine production in LDLR+/+ and LDLR−/− mice infected with S. typhimurium.

, 2013
LDLR−/− and control (LDLR+/+) C57Bl/6J mice were infected i.v. with 102 cfu of S. typhimurium. After 1, 3 or 7 days, groups of 5 mice/group were sacrificed, and circulating concentrations of cytokines in the plasma were measured by specific ELISA.
Leo A. B. Joosten (195019), Monique Keuter (374995), Mihai G. Netea (105648), Jos W. M. van der Meer (4959343), Frank Wagener (374997), Anton F. H. Stalenhoef (374998), Bart Jan Kullberg (195031)   +6 more
core   +1 more source

Berberine decreases plasma triglyceride levels and upregulates hepatic TRIB1 in LDLR wild type mice and in LDLR deficient mice [PDF]

Scientific Reports, 2019
AbstractTRIB1 is a GWAS locus associated with plasma cholesterol and triglycerides (TG) levels. In mice, liver-specific overexpression of TRIB1 lowers plasma lipid levels. Berberine (BBR) is a natural lipid lowering drug that reduces plasma LDL-cholesterol (LDL-C), total cholesterol (TC) and TG in hyperlipidemic patients and in mice by mechanisms ...
Singh, Amar Bahadur, Liu, Jingwen
openaire   +2 more sources

Real-World Experience from Türkiye: Genetic and Therapeutic Insights in Pediatric Heterozygous Familial Hypercholesterolemia

JCRPE
Objective: Familial hypercholesterolemia (FH) is an inherited metabolic disorder that increases cardiovascular risk from childhood. Despite its frequency, pediatric diagnosis and treatment remain limited, particularly in developing countries.
Havva Yazıcı, Esra Er, Fehime Erdem, Ayşe Yüksel Yanbolu, Sakina Mammadova, Sedef Alpdoğan, Merve Yoldaş Çelik, Yasemin Atik Altınok, Ebru Canda, Ayça Aykut, Haluk Akın, Sema Kalkan Uçar, Mahmut Çoker   +12 more
doaj   +1 more source

The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation

Journal of Lipid Research, 2013
Low density lipoprotein (LDL) cholesterol is taken up into cells via clathrin-mediated endocytosis of the LDL receptor (LDLR). Following dissociation of the LDLR-LDL complex, LDL is directed to lysosomes whereas the LDLR recycles to the plasma membrane ...
Vincenzo Sorrentino, Jessica K. Nelson, Elena Maspero, André R.A. Marques, Lilith Scheer, Simona Polo, Noam Zelcer   +6 more
doaj   +1 more source