Results 81 to 90 of about 37,789 (262)

SUR1Δ/LDLR^-/- mice do not show differences in atherosclerotic plaque size or in plasma lipid levels when compared to LDLR^-/- mice.

, 2021
(A) Hematoxylin-eosin stained cross-sectional plaque area in the aortic root of SUR1Δ/LDLR-/- (n = 7) mice compared to LDLR-/- (n = 5) mice, (B) Plaque area in brachiocephalic artery in SUR1Δ/LDLR-/- (n = 8) and LDLR-/- (n = 5) mice, (C) Plasma levels of
Anssi Laine (11689866), Erika Gurzeler (4781904), Seppo Ylä-Herttuala (7542), Sanna Kettunen (11689872), Anna-Kaisa Ruotsalainen (11689863), Teemu Valkama (11689869), Markku Laakso (197777)   +6 more
core   +1 more source

Isogenic induced pluripotent stem cell line ICGi036-A-1 from a patient with familial hypercholesterolaemia, derived by correcting a pathogenic variant of the gene LDLR c.530C>T

Вавиловский журнал генетики и селекции
Familial hypercholesterolaemia is a common monogenic disorder characterized by high plasma cholesterol levels leading to chronic cardiovascular disease with high risk and often early manifestation due to atherosclerotic lesions of the blood vessels.
A. S. Zueva, A. I. Shevchenko, S. P. Medvedev, E. A. Elisaphenko, A. A. Sleptcov, M. S. Nazarenko, N. A. Tmoyan, S. M. Zakian, I. S. Zakharova   +8 more
doaj   +1 more source

Hepatic lipase overexpression lowers remnant and LDL levels by a noncatalytic mechanism in LDL receptor-deficient mice

Journal of Lipid Research, 2001
To address the role of the noncatalytic ligand function of hepatic lipase (HL) in low density lipoprotein (LDL) receptor-mediated lipoprotein metabolism, we characterized transgenic mice lacking the LDL receptor (LDLR) that express either catalytically ...
Helén L. Dichek, Sarah M. Johnson, Hassibullah Akeefe, Giai T. Lo, Ezra Sage, Christine E. Yap, Robert W. Mahley   +6 more
doaj   +1 more source

Multi‐omics–driven precision medicine

iMeta, EarlyView.
Multi‐omics‐driven precision medicine (MODPM) provides a multiscale, continuously learnable framework that integrates genomics, epigenomics, transcriptomics, proteomics, metabolomics, microbiome profiles, and clinical data. Powered by artificial intelligence and foundation models, MODPM enables cross‐modal representation learning, contextual modeling ...
Huibo Li, Zhe Zhao, Yifan Zhang, Yao Ma, Gaofei Hu, Min Zeng, Zhanqun Yang, Zixuan Zhao, Xin Zhou, Wei Hu, Yuxuan Sun, Meng Su, Jun Li, Matthew Whiteman, Wei Fu, Chao Zhong, Lemin Zheng, Long Chen, Hairong Lv, Rongsheng Zhao, Yi Zhun Zhu   +20 more
wiley   +1 more source

Chrysin 7‐O‐β‐d‐glucopyranoside increases hepatic low‐density lipoprotein receptor expression through AMP‐activated protein kinase activation

FEBS Open Bio, 2023
Elevated plasma low‐density lipoprotein (LDL) cholesterol level is a risk factor for developing atherosclerosis. Increased LDL receptor (LDLR) expression is expected to reduce the risk of atherosclerotic disease since hepatic LDLR is essential for ...
Naoki Kaname, Takahiro Fujimaki, Shotaro Horikoshi, Kaito Fujimura, Manami Kodaka, Shinnosuke Wakamori, Ryo Katsuta, Ken Ishigami, Tsukasa Suzuki, Yuji Yamamoto, Jun Inoue   +10 more
doaj   +1 more source

Non‐Nutritive Artificial Sweeteners Aspartame and Acesulfame‐K Ameliorate Metabolic Dysfunction‐Associated Steatotic Liver Disease in Male Ldlr−/− Mice

iNew Medicine, EarlyView.
ABSTRACT Aspartame and acesulfame‐K are commonly used non‐nutritive artificial sweeteners, but their impacts on cardiovascular disease and metabolic dysfunction‐associated fatty liver disease (MASLD) are unclear. In this study, we evaluated the impacts of aspartame and acesulfame‐K on MASLD and atherosclerosis in male Ldlr−/− mice fed an AMLN diet ...
Jingjing Xu, Xiaohua Jiang, Jianping Weng, Suowen Xu   +3 more
wiley   +1 more source

Emerging Human‐Based Research Technologies for Investigating the Pathomechanisms and Therapies for Vascular Diseases

iNew Medicine, EarlyView.
ABSTRACT It is estimated that a large proportion of drug candidates fail in human clinical trials, mainly because animal models cannot fully replicate human disease and because of differential responses to various medications between humans and animals.
Weiping Ding, Iqra Ilyas, Suowen Xu
wiley   +1 more source

Summary of total cholesterol from LDLR+/+, LDLR+/−, and LDLR−/− pigs fed a high fat, high cholesterol diet for 90 and 180 days.

, 2014
All values are presented with SD.
Christopher S. Rogers (545570), Jason T. Struzynski (545565), Frank A. Rohret (545568), Timothy C. Nichols (545569), Bryan T. Davis (545563), Elizabeth P. Merricks (545566), Judy A. Rohret (545564), Xiao-Jun Wang (321924), Dwight A. Bellinger (545567)   +8 more
core   +1 more source

Genetic Patterns in LDLR Gene Polymorphism among Individuals with Co-Existing Diabetes and Coronary Artery Disease

Medical Journal of Babylon
Background: This research investigates the association between genetic polymorphism in the low-density lipoprotein receptor (LDLR) gene and type 2 diabetes mellitus (T2DM) with coronary artery disease (CAD).
Mohammed Noori Salman, Thekra Abid Jaber Al-Kashwan, Abdulhussein Alwan Faraj Aljanabi   +2 more
doaj   +1 more source

Aortic valve calcium score in hypercholesterolemic patients with and without low-density lipoprotein receptor gene mutation.

PLoS ONE, 2018
The aim of this study was a comparison of aortic valve calcium score (AVCS) between patients with hypercholesterolemia and genetic diagnosis of familial hypercholesterolemia with low-density lipoprotein receptor gene mutation (LDLR-M group), versus ...
Rafal Gałąska, Dorota Kulawiak-Gałąska, Magdalena Chmara, Krzysztof Chlebus, Michał Studniarek, Marcin Fijałkowski, Bartosz Wasąg, Andrzej Rynkiewicz, Marcin Gruchała   +8 more
doaj   +1 more source