Results 101 to 110 of about 37,789 (262)
Small, EarlyView.ABSTRACT Targeting iron‐dependent ferroptosis with siRNA has emerged as a promising strategy for cancer treatment. The concept of ferrous‐supply regeneration, inspired by electro‐Fenton technology, has also gained interest as a non‐apoptotic approach to induce ferroptosis.
Dun Hu +6 more
wiley +1 more source
Microgliosis is decreased in the brains of 5XFAD/LDLR-/- and 5XFAD/ApoE-/-LDLR-/- mice.
, 2013 A. Immunohistochemistry for Iba1 (red) and Thioflavine-S (green) in the hippocampus and cortex of mouse brains. Representative pictures are shown for each genotype.
Spiros Georgopoulos (348709) +1 more
core +1 more source
GRP94 Regulates Circulating Cholesterol Levels through Blockade of PCSK9-Induced LDLR Degradation
Cell Reports, 2015 Clearance of circulating low-density lipoprotein cholesterol (LDLc) by hepatic LDL receptors (LDLR) is central for vascular health. Secreted by hepatocytes, PCSK9 induces the degradation of LDLR, resulting in higher plasma LDLc levels.
Steve Poirier +4 more
doaj +1 more source
Proximity Proteomics Maps Candidate Cellular Uptake Pathways for Cell‐Derived Nanovesicles
Small Methods, EarlyView.TurboID‐based dual‐sided proteomics compares mechanically generated cell‐derived nanovesicles with naturally secreted small extracellular vesicles. Vesicle proteomes define candidate interaction signatures, while recipient‐cell proximity labelling identifies exposure‐associated proteins.
Eisuke Kanao +8 more
wiley +1 more source
LDLR dysfunction induces LDL accumulation and promotes pulmonary fibrosis
, 2022 Treatments for pulmonary fibrosis (PF) are ineffective because its molecular pathogenesis and therapeutic targets are unclear. Here, we show that the expression of low‐density lipoprotein receptor (LDLR) was significantly decreased in alveolar type II ...
Dayan Sun +39 more
core +1 more source
PCSK9 Prosegment Chimera as Novel Inhibitors of LDLR Degradation
PLoS ONE, 2013 The proprotein convertase PCSK9, a target for the treatment of hypercholesterolemia, is a negative regulator of the LDL receptor (LDLR) leading to its degradation in endosomes/lysosomes and up-regulation of plasma LDL-cholesterol levels. The proprotein convertases, a family of nine secretory serine proteases, are first synthesized as inactive zymogens.
Luna Saavedra, Y.G. +2 more
openaire +4 more sources
Journal of Lipid Research, 2014 It is well-established that over-accumulation of dietary cholesterol in the liver inhibits sterol-regulatory element binding protein (SREBP)-mediated LDL receptor (LDLR) gene transcription leading to a reduced hepatic LDLR mRNA level in ...
Amar Bahadur Singh +4 more
doaj +1 more source
VIEW, EarlyView.In this study, we analyzed data from the Kailuan study in China (N = 95,711) and the UK Biobank (N = 388,317), comprising adults free of CMDs at baseline. The results demonstrated distinct, population‐specific patterns regarding how blood lipids influence the transition from a healthy state to incident CMDs and subsequently to CMM.
Lili Huang +16 more
wiley +1 more source
Overview of the experiments that were conducted in C57BL/6J LDLR+/+ and LDLR-/- mice.
, 2016 Overview of the experiments that were conducted in C57BL/6J LDLR+/+ and LDLR-/- mice.
Silke Verhelle (2833088) +6 more
core +1 more source
Neurobiology of Disease, 2014 Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. APOE ε4 is a major genetic risk factor for cardiovascular disease (CVD) and Alzheimer's disease (AD). ApoE mediates cholesterol metabolism by binding various receptors.
Lance A. Johnson +7 more
doaj +1 more source