Results 121 to 130 of about 37,789 (262)
British Journal of Pharmacology, EarlyView.The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli +6 more
wiley +1 more source
Protein and mRNA expression of wt LDLR and LDLR variants in CHO-ldlA7 transfected cells.
, 2014 Cells were transfected with the corresponding plasmids carrying the mutations of interest, LDLR was overexpressed for 48 h and then (A) protein expression was analyzed by Western blot, (B) the relative band intensities of both mature and precursor LDLR ...
Helena Ostolaza (229309) +5 more
core +1 more source
Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor
Journal of Lipid Research, 2007 LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear.
Britta Loeffler +6 more
doaj +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim To develop a next‐generation, longer‐acting, more‐clinical‐benefits agonist to achieve sustained efficacy with improved tolerability. Methods CT130 was designed from semaglutide. Binding affinity was validated via molecular dynamics and cellular assays.
Wei Ding +4 more
wiley +1 more source
Astrocytosis is decreased in the brains of 5XFAD/LDLR-/- and 5XFAD/ApoE-/- LDLR-/- mice.
, 2013 Immunohistochemistry for GFAP (red) and Thioflavine-S (green) in the hippocampi (A) and the cortices (B) of mouse brains. Representative pictures are shown for each genotype.
Spiros Georgopoulos (348709) +1 more
core +1 more source
Journal of Hepatocellular CarcinomaTian Chen,1 Lunjian Xiang,2 Wenjin Zhang,3 Zhenyi Xia,4,* Weixian Chen1,* 1Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China; 2Hepatobiliary Surgery, Chongqing
Chen T, Xiang L, Zhang W, Xia Z, Chen W
doaj
CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Hypocholesterolemia in liver and cardiovascular disease: Friend or foe?
Journal of Internal Medicine, EarlyView.Abstract Hypocholesterolemia is perceived as benign given its association with lower cardiovascular risk. However, genetic and epidemiological evidence indicates that persistently low levels of low‐density lipoprotein cholesterol (LDL‐C) and apolipoprotein B (ApoB) arise from distinct biological mechanisms with different hepatic implications ...
Valentina Flagiello +3 more
wiley +1 more source
The LDLR D310 interactions with PCKS9.
, 2019 Conversion of one oxygen atom of the carboxyl group (A) from LDLR D310 to VDW representation shows how deeply it penetrates the LDLR Ca2+ ion as a chelating group.
John L. Kulp III (4389241) +3 more
core +1 more source
Sexual dimorphism in atherosclerotic plaques of aged Ldlr−/− mice
Immunity & AgeingAbstract Background Atherosclerosis, the main underlying pathology of cardiovascular disease, is a chronic inflammatory disease characterized by lipid accumulation and immune cell responses in the vascular wall, resulting in plaque formation. It is well-known that atherosclerosis prevalence and manifestation vary by sex.
Smit, Virginia +7 more
openaire +4 more sources