Results 141 to 150 of about 37,789 (262)
Aging Cell, Volume 25, Issue 10, October 2026.α‐Syn‐HDOs protect dopaminergic neurons by enhancing BDNF–TrkB signaling through the inhibition of abnormally elevated α‐Syn. These findings position α‐Syn‐HDOs as promising therapeutic candidates for PD and suggest that BDNF may serve as a potential diagnostic biomarker or indicator of treatment efficacy.
Xuenan Wang +9 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5732-5751, October 2026.Abstract Cardiovascular disease (CVD) remains the leading global cause of death, driven by complex mechanisms, in which chronic inflammation plays a central role. Inflammatory pathways contribute to all stages of CVD, from endothelial dysfunction and plaque formation to erosion, rupture and myocardial injury.
Shreya Mahabhashyam +4 more
wiley +1 more source
Identification of mutations induced by ldlr TALEN.
, 2014 (A) A schematic diagram showing primers for detecting mutations in TALEN target sites of ldlr gene. (B) The relative amplification efficiency of ldlr Pf primers to Po primers.
Chuan Yu (573089) +3 more
core +1 more source
The FASEB Journal, Volume 40, Issue 18, 30 September 2026.Bidirectional communication between oocytes and granulosa cells undergoes progressive remodeling during bovine folliculogenesis. Integrative transcriptomic analysis identified stage‐specific ligand‐receptor signaling networks coordinating structural, metabolic, and developmental processes.
Noemi Monferini +6 more
wiley +1 more source
LDLR deletion increases Aβ deposition in the mouse hippocampus.
, 2013 A. Immunohistochemistry for total Aβ (6E10) in the brains of female mice. Representative pictures are shown for each genotype. The Aβ deposition is increased in the subiculum of the 5XFAD/LDLR-/- mice compared to the 5XFAD mice.
Spiros Georgopoulos (348709) +1 more
core +1 more source
Advanced Science, Volume 13, Issue 53, 24 September 2026.As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang +11 more
wiley +1 more source
Engineering Antibodies into Targeted Chimeras: From Recognition Modules to Programmable Degraders
Advanced Science, Volume 13, Issue 50, 7 September 2026.Antibody can be engineered into diverse lysosome‐targeting chimeras that convert target recognition into active degradation. By coupling antibody binding with recruited receptors, encoded domains, conjugated ligands, or nanoparticle scaffolds, these antibody‐associated targeted chimeras (AbTACs) platforms direct extracellular and membrane proteins ...
Kaige Chen, Quanyin Hu
wiley +1 more source
High-throughput microscopy characterisation of rare LDLR variants
, 2021 Aim: Mutations in the Low Density Lipoprotein receptor (LDLR) gene are the major cause of familial hypercholesterolaemia (FH), with over 2300 variants described in clinical FH patients.
Graça, Rafael
core
Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathological change (LATE‐NC) frequently co‐occurs with Alzheimer's disease neuropathologic change (ADNC), complicating classification.
Qi Qiao +9 more
wiley +1 more source
Barrier Immunity, Volume 2, Issue 3, Page 131-146, September 2026.ABSTRACT RNA sequencing (RNA‐seq) analysis revealed transcriptional features indicative of sustained immunosuppression within regulatory T cells (Tregs) isolated from atherosclerotic tissues, highlighting the critical contribution of immune checkpoint (ICP) receptor–ligand interactions to atherosclerosis progression. To comprehensively characterize the
Ying Shao +16 more
wiley +1 more source