Results 111 to 120 of about 37,789 (262)
Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions
Allergy, EarlyView.Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira +13 more
wiley +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
PCSK9 and LDLR in hepatic endosomes
, 2019 PCSK9 binds to LDLR sending it to degradation, thus avoiding its recycling back to the cell membrane of the hepatocyte.
Olivia Tort (7545545)
core +1 more source
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source
Control of LDL Uptake in Human Cells by Targeting the LDLR Regulatory Long Non-coding RNA BM450697
, 2019 Hypercholesterolemia is a condition that is characterized by very high levels of cholesterol in the blood and is a major correlating factor with heart disease.
Taskova, M +5 more
core +1 more source
GW26-e2268 LDLR mutations in China
Journal of the American College of Cardiology, 2015 Familial hypercholesterolemia (FH) is a common and serious dominant genetic disease, which characteristic by tendon xanthoma, severely elevated LDL cholesterol (LDL-C) and premature coronary heart disease.
Jiang, Long +5 more
openaire +1 more source
Journal of Lipid Research, 2001 The low density lipoprotein receptor (LDLR) plays a major role in regulation of plasma cholesterol levels as a ligand for apolipoprotein B-100 and apolipoprotein E (apoE).
Masa-aki Kawashiri +5 more
doaj +1 more source
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
A Deep Intronic Variant in LDLR in Familial Hypercholesterolemia.
Circulation. Genomic and precision medicine, 2018 Familial hypercholesterolemia (FH) is an inherited disorder characterized by high plasma LDL-C (low-density lipoprotein-cholesterol) levels. The vast majority of FH patients carry a mutation in the coding region of LDLR, APOB, or PCSK9. We set out to identify the culprit genetic defect in a large family with clinical FH, in whom no mutations were ...
Reeskamp, Laurens F. +7 more
openaire +2 more sources
Participation of macrophages in atherosclerotic lesion morphology in LDLr−/− mice
Journal of Lipid Research, 2004 Lystbeige (beige) mice crossed with LDL receptor-deficient (LDLr−/−) mice had a distinct atherosclerotic lesion morphology that was not observed in LDLr−/− mice. This morphology is often associated with a stable plaque phenotype.
Natalie K. Schiller +4 more
doaj +1 more source