Results 1 to 10 of about 121,670 (308)
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content [PDF]
Journal of Lipid ResearchApolipoprotein A-V (APOA5) is a critical regulator of circulating triglyceride (TG) levels. Its deletion leads to elevated plasma TG concentrations by altering the metabolism of VLDL particles in vivo.
Pheruza Tarapore +8 more
doaj +2 more sources
Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]
Journal of Integrative Neuroscience, 2021 Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing +5 more
doaj +1 more source
TREM2 coding variants in Slovak Alzheimer's disease patients
Journal of Integrative Neuroscience, 2022 Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of ...
Vladimira Durmanova +9 more
doaj +1 more source
Annals of General Psychiatry, 2021 Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of ...
Wenwang Rao +4 more
doaj +1 more source
Association of apolipoprotein ε4 allele with intellectual disability in children with cerebral palsy
Archives of Mental Health, 2023 Background: The apolipoprotein E (ApoE) protein is the most essential lipid transporter in the brain which is vital in neurodevelopment. The production of ApoE is regulated by several genes and increases under certain conditions such as cerebral injury.
N Sreedevi +4 more
doaj +1 more source
Apolipoprotein E and Alzheimer's Disease [PDF]
Annual Review of Neuroscience, 1995 The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrasL the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant
W J, Strittmatter, A D, Roses
openaire +3 more sources
Journal of Lipid Research, 2009 Apolipoprotein E (apoE) is an exchangeable apolipoprotein that functions as a ligand for members of the LDL receptor family, promoting lipoprotein clearance from the circulation. Productive receptor binding requires that apoE adopt an LDL receptor-active
Paul S. Hauser +6 more
doaj +1 more source
Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Journal of Neuroinflammation, 2004 The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D +4 more
doaj +1 more source
Apolipoprotein E is secreted by cultured lipocytes of the rat liver.
Journal of Lipid Research, 1991 Hepatic lipocytes, the retinoid-storing cells of the liver, share several characteristics with vascular smooth muscle cells. To determine whether they also share the characteristic of apolipoprotein E secretion, we have compared the relative mRNA ...
G Friedman +3 more
doaj +1 more source
Apolipoprotein E Interferes with IAPP Aggregation and Protects Pericytes from IAPP-Induced Toxicity
Biomolecules, 2020 Apolipoprotein E (ApoE) has become a primary focus of research after the discovery of its strong linkage to Alzheimer’s disease (AD), where the ApoE4 variant is the highest genetic risk factor for this disease.
Anna L. Gharibyan +9 more
doaj +1 more source