Results 11 to 20 of about 103,941 (262)
Apolipoprotein A5 reduces clearance of VLDL by altering apolipoprotein E content [PDF]
Journal of Lipid ResearchApolipoprotein A-V (APOA5) is a critical regulator of circulating triglyceride (TG) levels. Its deletion leads to elevated plasma TG concentrations by altering the metabolism of VLDL particles in vivo.
Pheruza Tarapore +8 more
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Apolipoprotein E ε4 and ε3 alleles associate with cerebrospinal fluid tau and cognition in the presence of amyloid-𝜷 in mild cognitive impairment but not in Alzheimer’s disease [PDF]
Journal of Integrative Neuroscience, 2021 Apolipoprotein E is the most well-established genetic risk factor for Alzheimer’s disease. However, the associations of apolipoprotein E with tau pathology and cognition remain controversial.
Feng Xing +5 more
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Annals of General Psychiatry, 2021 Background The apolipoprotein E (ApoE) gene polymorphisms are correlated with blood lipid levels and several neuropsychiatric symptoms. Therefore, this study aimed to examine whether the ApoE rs429358 affected the development and clinical symptoms of ...
Wenwang Rao +4 more
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Toxic Metals Exposure and APOE4 Gene Variant in Cognitive Decline Disorders [PDF]
Archives of Razi Institute, 2022 Neurodegenerative disorders are those which affect cognitive functions. Misfolding of proteins especially apolipoprotein E is a key genetic factor involved in several cognitive impairments. Increasing evidence also described the toxic effects of metals,
A Gasmi, A Menzel, S Piscopo, S Noor
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TREM2 coding variants in Slovak Alzheimer's disease patients
Journal of Integrative Neuroscience, 2022 Background: Triggering receptor expressed on myeloid cells 2 (TREM2) is an important modulator of innate immune responses. In the human brain, TREM2 is primarily expressed on microglia and is involved in cell survival, phagocytosis, and regulation of ...
Vladimira Durmanova +9 more
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Apolipoprotein E and Alzheimer's Disease [PDF]
Annual Review of Neuroscience, 1995 The apolipoprotein E locus (APOE) is associated with variations in the age of onset and risk of Alzheimer's disease. The APOE4 allele increases the probability of disease at an earlier age. In contrasL the APOE3 and APOE2 alleles decrease the probability of disease and increase the age of onset. Therefore the metabolism of apolipoprotein E is relevant
W J, Strittmatter, A D, Roses
openaire +3 more sources
Journal of Lipid Research, 2009 Apolipoprotein E (apoE) is an exchangeable apolipoprotein that functions as a ligand for members of the LDL receptor family, promoting lipoprotein clearance from the circulation. Productive receptor binding requires that apoE adopt an LDL receptor-active
Paul S. Hauser +6 more
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Apolipoprotein E gene polymorphisms as risk factors for carotid atherosclerosis [PDF]
Vojnosanitetski Pregled, 2014 Background/Aim. Atherosclerosis is still the leading cause of death in Western world. Development of atherosclerotic plaque involves accumulation of inflammatory cells, lipids, smooth muscle cells and extracellular matrix proteins in the intima ...
Zurnić Irena +5 more
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Similar promotion of Aβ1-42 fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms
Journal of Neuroinflammation, 2004 The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease.
Smith Jonathan D +4 more
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Association of apolipoprotein ε4 allele with intellectual disability in children with cerebral palsy
Archives of Mental Health, 2023 Background: The apolipoprotein E (ApoE) protein is the most essential lipid transporter in the brain which is vital in neurodevelopment. The production of ApoE is regulated by several genes and increases under certain conditions such as cerebral injury.
N Sreedevi +4 more
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