Results 31 to 40 of about 103,941 (262)
Journal of Lipid Research, 2012 Mipomersen, an antisense oligonucleotide that reduces hepatic production of apoB, has been shown in phase 2 studies to decrease plasma apoB, LDL cholesterol (LDL-C), and triglycerides.
Jeremy D. Furtado +2 more
doaj +1 more source
IMPORTANCE OF PLASMA E APOLYPROTEIN DOSAGE, OF GENETIC POLYMORPHISM AND LIPID PROFILE IN DIABETIC PATIENTS [PDF]
Romanian Journal of Medical Practice, 2019 Apolipoproteine E (ApoE) is known for its ability to suppress atherosclerosis. Besides its activity to remove the remaining lipoproteins from plasma, ApoE is also known for its direct influence on the numerous cells of the vascular walls, immune system ...
Silviu Daniel Moldovan +4 more
doaj +1 more source
Molecular mechanisms and genetics of Alzheimer’s disease
Türk Biyokimya Dergisi, 2023 Dementia is mostly caused by neurodegenerative diseases like Alzheimer’s disease (AD). AD is the most common form of dementia. It is caused by both genetic and environmental factors.
Öztan Gözde, İşsever Halim
doaj +1 more source
Apolipoprotein £ and Epilepsy [PDF]
Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1996 The overall frequencies of the apolipoprotein f2, f3 and f4 alleles in the epilepsy patients were no different to those of the control group (Table 1). Subgroups consisting of patients with either an unknown aetiology for epilepsy (71% of patients), a family history of epilepsy (21% of patients), idiopathic generalized epilepsy, or cryptogenic partial ...
E S, Kilpatrick +3 more
openaire +2 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
APOLIPOPROTEIN E AND THE PROGRESSION OF RENAL NEPHROPATHY IN PACIENTS WITH DIABETES [PDF]
Romanian Medical Journal, 2019 Apolipoprotein (Apo) E plasma is a key factor of lipid metabolism. It is a surface component of triglycerides-rich lipoproteins, low-density lipoproteins (VLDL), chylomicron remnants and high-density lipoproteins (HDL).
Silviu Daniel Moldovan +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Functional significance of polymorphism of ApoE and SOD2 genes in formation of chronic HCV infection
Бюллетень сибирской медицины, 2009 The analysis of gene polymorphism plays an important role in assessment of disposition to infectious diseases at the population and individual level. In this paper, the frequencies of allelic versions of apolipoprotein E and 2nd type superoxide dismutase
N. A. Semyonova +6 more
doaj +1 more source
FEBS Open Bio, EarlyView.In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin +12 more
wiley +1 more source
Indian Journal of Dermatology, 2023 Background: Apolipoprotein E (APOE) gene isoforms have been found to affect the risk of superficial fungal infections (SFIs). However, the data only cover a few ethnicities.
Amany I Mustafa +5 more
doaj +1 more source