Results 1 to 10 of about 28,066 (219)

The PCSK9 decade

Journal of Lipid Research, 2012
PCSK9 proprotein convertase subtilisin/kexin type (PCSK9) is a crucial protein in LDL cholesterol (LDL-C) metabolism by virtue of its pivotal role in the degradation of the LDL receptor.
Gilles Lambert, Barbara Sjouke, Benjamin Choque, John J.P. Kastelein, G. Kees Hovingh   +4 more
doaj   +2 more sources

Conditional knockdown of hepatic PCSK9 ameliorates high-fat diet-induced liver inflammation in mice

Frontiers in Pharmacology
InstructionAccumulating evidence has shown that proprotein convertase subtilisin/kexin type 9 (PCSK9) is associated with inflammation in the vascular system. However, the roles of PCSK9 in hepatic inflammation remain unclear.
Xue-Ying Zhang, Qing-Qing Lu, Yan-Jie Li, Shan-Rui Shi, Chao-Nan Ma, Miao Miao, Shou-Dong Guo   +6 more
doaj   +1 more source

The interrelations between PCSK9 metabolism and cholesterol synthesis and absorption

Journal of Lipid Research, 2019
Very few studies have investigated the interrelations between proprotein convertase subtilisin/kexin type 9 (PCSK9) metabolism, cholesterol synthesis, and cholesterol absorption.
Günther Silbernagel, Lars K. Steiner, Tim Hollstein, Günter Fauler, Hubert Scharnagl, Tatjana Stojakovic, Friederike Schumann, Bediha Bölükbasi, Winfried März, Elisabeth Steinhagen-Thiessen, Ulrich Laufs, Ursula Kassner   +11 more
doaj   +1 more source

ASSOCIATION OF LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) WITH PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) IN FAMILIAL HYPERCHOLESTEROLEMIA

Атеросклероз, 2019
Objective was to study the levels and the relationship between lipoprotein-associated phospholipase A2 (Lp-PLA2) and proprotein convertase subtilisin/kexin type 9 (PCSK9), their relationship with other lipid parameters in patients with familial ...
K. S. Benimetskaya, V. S. Shramko, E. M. Stakhneva, K. V. Makarenkova, L. V. Shcherbakova, Yu. I. Ragino, M. I. Voevoda   +6 more
doaj   +1 more source

Contrasting effects of intracellular and extracellular human PCSK9 on inflammation, lipid alteration and cell death

Communications Biology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is one of the major regulators of low-density lipoprotein receptor (LDLR). Information on role and regulation of PCSK9 in lung is very limited.
Aram Ghalali, Fahd Alhamdan, Swapna Upadhyay, Koustav Ganguly, Kjell Larsson, Lena Palmberg, Mizanur Rahman   +6 more
doaj   +1 more source

The role of proprotein convertase subtilisin/kexin type 9 inhibitors in managing cardiovascular risk

South African Family Practice, 2016
Hypercholesterolaemia and dyslipidaemia, marked by decreased levels of high-density lipoprotein and elevated levels of lowdensity lipoprotein (LDL), increase the risk of cardiovascular disease.
Natalie Schellack, Gustav Schellack, E. Bronkhorst   +2 more
doaj   +1 more source

PCSK9 is upregulated and correlated with more severe disease condition but fails to predict treatment outcomes in psoriasis patients

Journal of Dermatological Treatment
Background Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) not only regulates cholesterol metabolism and cardiovascular disorder but also modifies inflammatory response and autoimmunity.Objective This study investigated the relation of PCSK9 to ...
Xuwen Yin, Lei Shi, Ni Zhang, Heng Li, Jianwen Long, Xinjian Yu   +5 more
doaj   +1 more source

ASSOCIATION OF PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 WITH HYPERTENSION AND SMOKING

Инновационная медицина Кубани, 2019
Objectives. To estimate the relationship of proprotein convertase subtilisin/kexin type 9 (PCSK9) level with blood pressure (BP) and smoking in a population of young males in Novosibirsk.Material and methods.
K. S. Benimetskaya, M. P. Yachmeneva, S. V. Astrakov, L. V. Shcherbakova, D. V. Denisova, Yu. I. Ragino, M. I. Voevoda   +6 more
doaj  

Serum HMGB3 and PCSK9 Levels as Predictors of Early Treatment Response in Pediatric <i>Mycoplasma pneumoniae</i> Pneumonia: A Single-Center Prospective Cohort Study. [PDF]

Int J Gen Med
Gao H, Yu Y, Lyu D.
europepmc   +1 more source

PCSK9-Mediated Inflammation in Foam Cell Formation and Exploring the Biologically Active Compounds Derived From Natural Resources. [PDF]

Adv Pharmacol Pharm Sci
Wisesa MHM, Mathriul AQ, Suswidiantoro V, Puteri MU, Kato M, Idris MHM, Saputri FC.   +6 more
europepmc   +1 more source