Results 21 to 30 of about 37,789 (262)
Hepatology, EarlyView., 2022 The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol +22 more
wiley +1 more source
LDLR-Gene therapy for familial hypercholesterolaemia: Problems, progress, and perspectives [PDF]
, 2010 Coronary artery diseases (CAD) inflict a heavy economical and social burden on most populations and contribute significantly to their morbidity and mortality rates.
Charles Coutelle +11 more
core +1 more source
HVC1 ameliorates hyperlipidemia and inflammation in LDLR−/− mice [PDF]
BMC Complementary and Alternative Medicine, 2017 HVC1 consists of Coptidis Rhizoma (dried rhizome of Coptischinensis), Scutellariae Radix (root of Scutellariabaicalensis), Rhei Rhizoma (rhizome of Rheum officinale), and Pruni Cortex (cortex of Prunusyedoensis Matsum). Although the components are known to be effective in various conditions such as inflammation, hypertension, and hypercholesterolemia ...
Cheon, Se-Yun +7 more
openaire +4 more sources
Common Mutations in LDLR Gene in Familial Hypercholesterolemia
مجله دانشگاه علوم پزشکی گرگان, 2022 Background and Objective: Familial hypercholesterolemia (FH) is one of the most common inherited familial diseases that cause lipid accumulation in tendons and arteries by increasing the level of low density plasma lipoprotein (LDL). The main cause of FH
Fatemeh Vali Mohammadi Rahmani +2 more
doaj
Would raising the total cholesterol diagnostic cut-off from 7.5 mmol/L to 9.3 mmol/L improve detection rate of patients with monogenic familial hypercholesterolaemia? [PDF]
, 2015 A previous report suggested that 88% of individuals in the general population with total cholesterol (TC) > 9.3 mmol/L have familial hypercholesterolaemia (FH). We tested this hypothesis in a cohort of 4896 UK civil servants, mean (SD) age 44 (±6) years,
Humphries, S.E. +9 more
core +1 more source
T Cells in Atherosclerosis in Ldlr-/- and Apoe-/- Mice [PDF]
Journal of Immunological Sciences, 2018 Atherosclerosis is the underlying basis for most cardiovascular diseases. It is a chronic inflammation affecting the arterial intima and is promoted by hypercholesterolemia. Cells of both the innate and adaptive immune systems contribute to this inflammation with macrophages and T cells being the most abundant immune cells in the atherosclerotic ...
Getz, Godfrey S., Reardon, Catherine A.
openaire +2 more sources
Small Molecule Inhibitors of the PCSK9·LDLR Interaction [PDF]
Journal of the American Chemical Society, 2018 The protein-protein interaction between proprotein convertase subtilisin/kexin type 9 (PCSK9) and low-density lipoprotein receptor (LDLR) is a relatively new, and extremely important, validated therapeutic target for treatment and prevention of heart disease. Experts in the area agree that the first small molecules to disrupt PCSK9·LDLR would represent
Jaru Taechalertpaisarn +3 more
openaire +2 more sources
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +2 more sources
, 2022 Western diet-induced type 2 diabetes in genetically engineered ...
Weibin Shi (6481514)
core +1 more source
Вопросы вирусологииAim. The aim of this study was to search for human genes potentially involved in the pathogenesis of hepatitis C by multi-network bioinformatics linkage analysis of proteins involved in the stages of hepatitis C virus (HСV) attachment and entry ...
Ekaterina V. Anufrieva +4 more
doaj +1 more source