Results 91 to 100 of about 28,066 (219)

The role of PCSK9 in atherothrombosis

, 2023
Background-Purpose: PCSK9 is a serine protease which, in addition to its major role in endosomal and lysosomal degradation of the LDL receptor, which results in increased plasma LDL-cholesterol levels, exhibits several LDL receptor-independent actions on
Tsouka, Aikaterini, Τσούκα, Αικατερίνη   +1 more
core   +1 more source

Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization

Pharmacological Research
PCSK9 promotes the degradation of the low-density lipoprotein receptors and its inhibition by monoclonal antibodies or gene silencing approaches results in the reduction of plasma cholesterol levels coupled to that of cardiovascular events.
Silvia Pelucchi, Lorenzo Da Dalt, Giulia De Cesare, Ramona Stringhi, Laura D’Andrea, Filippo La Greca, Clara Cambria, Lina Vandermeulen, Elisa Zianni, Stefano Musardo, Silvia Roda, Fabrizia Bonacina, Sofia Nasini, Maria Giovanna Lupo, Nicola Ferri, Stefano Comai, Fabrizio Gardoni, Flavia Antonucci, Diego Scheggia, Monica Di Luca, Giuseppe Danilo Norata, Elena Marcello   +21 more
doaj   +1 more source

TRIM31–LOX‐1 Axis: A Novel Therapeutic Frontier in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis, driven by a vicious cycle of lipid accumulation and chronic inflammation, underlies most cardiovascular diseases. Macrophages exacerbate this process by internalizing oxidized low‐density lipoprotein (oxLDL), forming foam cells, and releasing inflammatory mediators. A recent study published in Circulation identified the TRIM31–
Qian Zhang, Cheng Xue Qin
wiley   +1 more source

PCSK9 promotes arterial medial calcification

, 2022
Background and aims A complex interplay among chronic kidney disease (CKD), lipid metabolism and aortic calcification has been recognized. Here we investigated the influence of kidney function on PCSK9 levels and its potential direct action on smooth ...
Canzano, Paola, Rattazzi, Marcello, Catapano, Alberico L., Ferri, Nicola, Camera, Marina, Faggin, Elisabetta, Lupo, Maria Giovanna, Baragetti, Andrea, Catapano, Alberico L, Bressan, Alessandro, Panighel, Giovanni, De Martin, Sara, Greco, Maria Francesca, Poggio, Paolo, Garofalo, Mariangela, Ruscica, Massimiliano, Donato, Maristella, Bollati, Valentina   +17 more
core   +1 more source

Proprotein convertase subtilisin/kexin type 9 deficiency in extrahepatic tissues: emerging considerations

Frontiers in Pharmacology
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is primarily secreted by hepatocytes. PCSK9 is critical in liver low-density lipoprotein receptors (LDLRs) metabolism.
Fengyuan Lu, En Li, Xiaoyu Yang, Xiaoyu Yang   +3 more
doaj   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

PCSK9 inhibition in the management of hyperlipidemia: focus on evolocumab

, 2016
Dirk J Blom,1 Ricardo Dent,2 Rita C Castro,2 Peter P Toth3,4 1Division of Lipidology, Department of Medicine, University of Cape Town, Cape Town, South Africa; 2Amgen, Inc., Thousand Oaks, CA, 3Ciccarone Center for the Prevention of Cardiovascular ...
Dent R, Castro RC, Toth PP, Blom DJ
core  

PCSK9

, 2018
Unknown 15 years ago, PCSK9 (proprotein convertase subtilisin/kexin type 9) is now common parlance among scientists and clinicians interested in prevention and treatment of atherosclerotic cardiovascular disease.
Sergio Fazio, Hagai Tavori, Michael D. Shapiro   +2 more
core   +1 more source

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

Analysis of Carbohydrates and Glycoconjugates by Matrix‐Assisted Laser Desorption/Ionization Mass Spectrometry: An Update for 2023–2024

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The use of MALDI mass spectrometry for the analysis of carbohydrates and glycoconjugates is a well‐established technique and this comprehensive review is the twelfth update of the original article published in 1999 and brings coverage of the literature to the end of 2024.
David J. Harvey
wiley   +1 more source