Results 101 to 110 of about 20,028 (211)
Amino Acid and Lipid Metabolism in Cancer: Mechanisms and Therapeutic Opportunities
MedComm, Volume 7, Issue 8, August 2026.Amino Acid and lipid metabolism in cancer: (A) Regulation of Amino acid transportation and metabolism in cancer. (B) The core organization of lipid metabolic reprogramming in cancer and their functional consequences. ABSTRACT Metabolic reprogramming is a defining feature of cancer and a major contributor to immune escape.
Zixu Wang +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 8, August 2026.Schematic diagram of the mechanism by which PM@RSV NPs alleviate AS via FOXM1 activation. ABSTRACT Atherosclerosis (AS) is closely linked to endothelial cell (EC) senescence and mitochondrial dysfunction, which impair vascular repair. Resveratrol (RSV) has antioxidant, anti‐inflammatory, and pro‐angiogenic effects, but its clinical use is restricted by
Li Xiao, Zexin Zhan, Ping Liu, Bing Qin
wiley +1 more source
PCSK9 antagonists and inflammation [PDF]
Atherosclerosis, 2018 M. Ruscica +3 more
openaire +4 more sources
British Journal of Pharmacology, Volume 183, Issue 16, Page 4512-4531, August 2026.The G protein–coupled receptor (GPCR) superfamily consists of the most common targets of approved drugs. Targeting GPCRs offers appealing avenues for therapeutic development. Antibodies and their fragments, such as single‐domain antibodies (VHHs or nanobodies), have emerged as useful alternatives to small molecule pharmacophores as building blocks in ...
Shivani Sachdev, Ross W. Cheloha
wiley +1 more source
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma +5 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 7403-7415, August 2026.ABSTRACT Aims Elevated lipoprotein(a) [Lp(a)] is a genetic ASCVD risk factor that often persists despite intensive LDL‐C lowering. We compared the efficacy and safety of emerging Lp(a)‐targeted therapies (siRNAs, antisense oligonucleotides and an oral assembly inhibitor) with PCSK9‐directed therapies.
Jihad Abu Zayed +4 more
wiley +1 more source
Contemporary Management of Aortic Stenosis: Timing of Intervention and Lifetime Valve Management
European Journal of Clinical Investigation, Volume 56, Issue 8, August 2026.As transcatheter treatment expands to younger and lower‐risk patients, aortic stenosis management is evolving from a single procedure to lifelong valve care. This review highlights the key challenges across the patient journey, from timely diagnosis and optimal intervention to durable valve performance, long‐term surveillance, and repeat intervention ...
Ottavia Cozzi, Thomas Pilgrim
wiley +1 more source
Journal of Internal Medicine, Volume 300, Issue 2, Page 131-152, August 2026.Abstract Type 2 diabetes (T2D) is a major global health concern strongly associated with atherosclerosis and subsequent macrovascular complications. These complications are the leading cause of death among T2D patients. Despite a decline in cardiovascular events over the last decade, individuals with T2D still have an approximately doubled risk ...
Dania Al‐Sharify +2 more
wiley +1 more source