Results 121 to 130 of about 28,066 (219)
The Journal of Physiology, EarlyView.Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild +3 more
wiley +1 more source
PCSK9 : pathophysiological and molecular studies
, 2022 Les maladies cardiovasculaires (MCV) dont fait partie l'athérosclérose, sont la principale cause de décès dans le monde et sont responsables de 17,9 millions de victimes chaque année.
Azar, Yara
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The Journal of Physiology, EarlyView.Abstract figure legend LIGHT is a mutual mediator of intestinal and oesophageal fibroblast inflammation with common as well as tissue‐specific effects. Hydroxylase inhibitors can selectively suppress inflammatory factors in both cell types, albeit targeting different signalling pathways.
Cian M. Ohlendieck +13 more
wiley +1 more source
Obtention of shark Heterodontus francisci anti-PCSK9 like antibody
, 2019 La hipercolesterolemia es la causa principal de enfermedades aterogénicas que concluyen en la reducción de la calidad de vida o la muerte en una gran población a nivel mundial.
WILIAM GENDEL BERNAL OROZCO
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The characterisation of the ectodomain shedding of the low density lipoprotein receptor [PDF]
, 2009 Includes abstract. Includes bibliographical references (leaves 142-155)
Parker, Ayesha
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Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Urolithin A (UA) and urolithin B (UB) are gut microbiota‐derived metabolites of ellagitannins reported to influence mitochondrial function, inflammation and muscle metabolism. Their comparative transcriptomic effects in human skeletal muscle cells remain undefined.
Yves Henrotin +8 more
wiley +1 more source
Comprehensive Assessment of PCSK9 Inhibitors for Lipid Management: Scientific Guidance Based on Drug Selection Recommendations for Chinese Medical Institutions [PDF]
Jiabao Li, Siyong Huang, Xiao Hu, Jisheng Chen Key Specialty of Clinical Pharmacy, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of ChinaCorrespondence: Jisheng Chen, Key Specialty of Clinical Pharmacy,
Huang S, Li J, Chen J, Hu X
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Aging Cell, Volume 25, Issue 10, October 2026.Mitochondrial fission‐fusion imbalance contributes to age‐related cardio‐cerebral diseases like Alzheimer's disease, Parkinson's disease, Cerebral Infarction, Arteriosclerosis, Myocardial Infarction, Cardiac valve disease, Hypertension, and Cardiomyopathy. This review summarizes its regulatory mechanisms and interventions.
Yuyao Yin, Zijian Li
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 9346-9355, October 2026.ABSTRACT Aim Cardiovascular disease (CVD) is the leading cause of mortality in individuals with diabetes. Diabetic kidney disease, closely related to CVD risk, is prevalent in up to 40% of this population. Emerging evidence suggests ceramide lipids as accurate biomarkers for CVD.
Kristina Pigsborg +10 more
wiley +1 more source
A PCSK9 gátló kezelés hatása a szekunder kardiovaszkuláris prevencióban
Bevezetés: A már egyszer kardiovaszkuláris eseményt elszenvedett betegek körében prognosztikai jelentőségű a hatékony szekunder prevenció részeként az egyre szigorúbb koleszterin célértékek elérése. Ugyanakkor, a betegek egy része nem tolerálja a sztatin
Berencsi, Fruzsina
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