Results 141 to 150 of about 28,066 (219)

Proteomics‐Based Identification of the Pyroptosis‐Related Biomarker PCSK9 and Its Association With the Pathogenesis of Rheumatoid Arthritis

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 9, September 2026.
ABSTRACT Rheumatoid arthritis (RA) is a common autoimmune disease, and early diagnosis is critical for effective treatment. This study aims to identify potential biomarkers related to pyroptosis through serum proteomics analysis, offering new insights for the early diagnosis of RA.
Lei Wang, Hao‐Jie Chen, Ting‐Ting Wu, Xin‐Yi Shen, Ying‐Ying Gao, Yu‐Feng Yin, Tian Ren, Xin Chu, Jing Cao, Tao Cheng, Ming‐Jun Wang   +10 more
wiley   +1 more source

PCSK9-antibodies fail to block PCSK9-induced inflammation in macrophages and cannot recapitulate protective effects of PCSK9-deficiency in experimental myocardial infarction

Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol homeostasis by regulating low-density lipoprotein (LDL) receptor levels. Despite its known effects on cholesterol metabolism, the role of PCSK9
Ehlert, Carolin, Zur Mühlen, Constantin von, Wolf, Dennis, Lindner, Diana, Rauterberg, Simon, Hilgendorf, Ingo, Schrepf, Paola, Vico, Tamara A., Koentges, Christoph, Von Ehr, Alexander, Westermann, Dirk, Peyronnet, Remi, Dufner, Bianca, Hein, Jennifer, Härdtner, Carmen   +14 more
core   +1 more source

Smart Design: Integrating Artificial Intelligence and Gene Editing for Advanced mRNA Therapeutics

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The challenges of mRNA therapy and the application of artificial intelligence and gene editing in the field of mRNA drugs. ABSTRACT Artificial intelligence (AI) and gene editing are increasingly being applied to the design and evaluation of mRNA therapeutics.
Haixing Shi, Shengbin Liu, Danni Dai, Shanhui Jiang, Tingchen Tian, Zhenyi Niu, Zhongzheng Xiang, Chaoyu Zou, Fang Liu, Xue Tang, Xin Jiang, Xiangrong Song   +11 more
wiley   +1 more source

SURPASS‐CVOT and the Emerging Biology of Cardiometabolic Benefit

Diabetes, Obesity and Metabolism, Volume 28, Issue 10, Page 8753-8756, October 2026.
Salvatore Corrao, Francesco Cosentino, Massimo Federici   +2 more
wiley   +1 more source

Type 2 Diabetes Mellitus Modifies the Prognostic Value of LDL Particle Size in Statin‐treated Patients With Coronary Artery Disease: A Large‐scale Cohort Study

MedComm, Volume 7, Issue 9, September 2026.
The LDL‐C/ApoB ratio, a marker of LDL size, showed significant prognostic value in statin‐treated CAD patients depending on diabetes status. A higher ratio was linked to lower cardiovascular risk only in patients with type 2 diabetes, suggesting it may be a superior biomarker for risk stratification beyond conventional lipids in this high‐risk group ...
Xiaohui Bian, Jining He, Chenxi Song, Rui Zhang, Sheng Yuan, Guofeng Gao, Kefei Dou   +6 more
wiley   +1 more source

Amino Acid Metabolism in Health and Disease

MedComm, Volume 7, Issue 9, September 2026.
This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su, Jinyu Liu, Xiaoliang Deng, Yanqun Luo, Haiping Xue, Lei Wang, Lianjun Xing, Tao Wu   +7 more
wiley   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, Volume 2, Issue 3, Page 522-548, September 2026.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Role of PCSK9 in breast cancer: a systematic review of its mechanistic pathways and clinical relevance. [PDF]

Front Pharmacol
Puteri MU, Suswidiantoro V, Nabila R, Setiawan R, Azmi NU, Saputri FC, Watanabe Y, Kato M.   +7 more
europepmc   +1 more source

PCSK9 inhibitors in neurodegenerative disorders: mechanisms, therapeutic potential, and clinical implications. [PDF]

Transl Neurodegener
Wang JDJ, Teo AYT, Xiao B, Chao Y, Zhou ZD, Tan BJ, Chan LL, Rosalie E, Tan EK.   +8 more
europepmc   +1 more source