Results 151 to 160 of about 28,066 (219)

Combating ageing beyond the cell: Emerging roles of extracellular proteostasis

The FEBS Journal, Volume 293, Issue 18, Page 5558-5584, September 2026.
Ageing challenges the body's ability to maintain a stable and functional proteome, leading to protein damage and aggregation both inside and outside cells. This review focuses on the less well understood mechanisms of extracellular protein quality control and how they become disrupted in ageing, particularly in neurodegenerative diseases.
Siddharth R. Venkatesh, Ivan Gallotta, Bolanle F. Olabiyi, Yoon Hee Choi, Sarah Inglesfield, Janet R. Kumita, Collin Y. Ewald, Della C. David   +7 more
wiley   +1 more source

Guideline for the Comprehensive Perioperative Management of Older Patients With Lung Cancer (2025)

Journal of Evidence-Based Medicine, Volume 19, Issue 3, September 2026.
ABSTRACT With the accelerating population aging, the number of older adult patients with lung cancer continues to increase. These patients often present with multiple chronic diseases and geriatric syndromes, resulting in more complex perioperative management and significantly increased surgical risks.
Daiping Li, Rui Liang, Birong Dong, Lunxu Liu, Ning Ge, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University   +6 more
wiley   +1 more source

Suun kautta annosteltavien PCSK9-estäjien kehittäminen

New alternative drugs have been developed to treat atherosclerosis, of which PCSK9-inhibitors are one of the most promising. PCSK9-inhibitors inhibit a protein called proprotein convertase subtilisin/kexin type 9, which affects the number of LDL ...
Eikkula, Kalle
core  

Gender and region disparities in plasma PCSK9 levels: a systematic review and meta-analysis. [PDF]

BMJ Public Health
Li T, Wang Z, Gong H, Wang T, Wang X, Yang Y, Yang R, Xu R, Yang B, Ma Y, Luo J, Jiao L.   +11 more
europepmc   +1 more source

Anti‐inflammatory agents in atherosclerosis—and a need for reform: Extraordinary claims require extraordinary evidence

Journal of Internal Medicine, Volume 300, Issue 3, Page 258-283, September 2026.
Abstract Since 1858, human atherosclerotic plaques have been shown to contain immune cells. But are these cells suitable therapeutic targets? Dozens of clinical trials of anti‐inflammatory agents other than colchicine have been performed in patients with clinically evident atherosclerosis.
Kevin Jon Williams
wiley   +1 more source

The Impact of PCSK9 Inhibitors on Circulatory Inflammation: Mechanisms, Evidence, and Application Prospects. [PDF]

JACC Asia
Bing-Yan D, Jing-Ya W, Yu-Juan Y, Xiang-Yu D, Hong-Mei L, Hui P, Yi-Ning Y, Xiao-Lin Y.   +7 more
europepmc   +1 more source

PCSK9 as a Potential Regulator of Endothelial Dysfunction: Mechanistic Insights and Future Directions. [PDF]

Int J Mol Sci
Mathriul AQ, Wisesa MHM, Suswidiantoro V, Puteri MU, Kato M, Saputri FC.   +5 more
europepmc   +1 more source

A New Option for the Management of Dyslipidemias: Advances in Research on the Small Interfering RNA Drug Inclisiran. [PDF]

Rev Cardiovasc Med
Wu X, Zhang J.
europepmc   +1 more source

Role of PCSK9 in hallmarks of cancer: From mechanisms to interventions (Review). [PDF]

Oncol Lett
Tang L, Yao S, Zhu Y, He Z, Ramos-Molina B, Xu Y.   +5 more
europepmc   +1 more source

Familial Hypercholesterolemia. [PDF]

Methodist Debakey Cardiovasc J
Iatan I, Genest J.
europepmc   +1 more source