Results 1 to 10 of about 6,572 (211)

A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus [PDF]

Pathogens, 2021
The aim of this study was to compare the virulence of porcine circovirus type 2 (PCV2) genotypes in dually inoculated pigs with both three genotypes (a, b, and d) of PCV2 and porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) versus pigs ...
Siyeon Yang, Taehwan Oh, Chanhee Chae
exaly   +7 more sources

Engineered PCV2 VLPs for Antigen Delivery: A Platform for Next-Generation Veterinary Vaccines. [PDF]

Transbound Emerg Dis
The capsid (Cap) protein of porcine circovirus type 2 (PCV2) self‐assembles into virus‐like particles (VLPs) that form stable, noninfectious nanoparticles with T = 1 icosahedral symmetry. Mimicking native virion architecture, these VLPs display antigens in a highly ordered array, conferring strong immunogenicity for both humoral and cellular responses.
Ding P, Liu Y, Wang C, Wang A.
europepmc   +2 more sources

Concomitant Infection With Porcine circovirus 2 and Porcine Epidemic Diarrhea Virus Does Not Increase Enteritis Severity in Experimentally Infected Weaned Piglets. [PDF]

Transbound Emerg Dis
Background Young pigs are often coinfected with porcine circovirus 2 (PCV2) and porcine epidemic diarrhea virus (PEDV). This study aimed to determine the impact of coinfection of pigs with PCV2 and PEDV. Forty 16‐day‐old crossbred mixed‐sex piglets were assigned to four groups (n = 10/group, NEG‐CONTROL, PCV2‐CONTROL, PCV2+PEDV, and PEDV‐CONTROL).
Gerber PF, Zhang J, Noel A, Wang B, Huang Y, Halbur PG, Opriessnig T.   +6 more
europepmc   +2 more sources

Development of Magnetic Particle-Based Chemiluminescence Immunoassays for Detecting PCV2 VLP- and Rep-Specific Antibodies and Their Combined Use for Immune Evaluation and Replication-Associated Exposure Assessment. [PDF]

Transbound Emerg Dis
Porcine circovirus 2 (PCV2) remains a major swine pathogen, and interpretation of capsid protein (Cap)–based serology is challenging in vaccinated populations because vaccine‐induced Cap antibodies overlap with replication‐associated serological signals.
Gou M, Song X, Fan J, Chen Z, Kuang Z, Lu M, Fan Z, Ge M.   +7 more
europepmc   +2 more sources

Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review. [PDF]

Transbound Emerg Dis
Over the past decade, porcine circoviruses (PCVs) have continued to pose a significant threat to global swine health, and pivotal discoveries have significantly reshaped our understanding of their biology and control. Extensive genomic surveillance has expanded porcine circovirus 2 (PCV2) genotyping from four to at least eight lineages, with PCV2d now ...
Zheng J, Zhang G, Li P, Ren L.
europepmc   +2 more sources

Field Evaluation of a Novel Combined Vaccine Against Porcine Circovirus Types 2a/d, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis With an Emphasis on Growth Performance. [PDF]

Vet Med Sci
A field trial on three commercial farms evaluated a combined vaccine targeting PCV2a/d, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Vaccinated pigs showed improved average daily weight gain, stronger immune responses against these pathogens, and significantly reduced viral and mycoplasmal loads and lesion severity, supporting its efficacy under
Suh J, Ham S, Na H, Kang I, Oh T, You Y, Park B, Chae C.   +7 more
europepmc   +2 more sources

Emergence of a Novel CRESS-DNA Virus Associated with Swine Reproductive Failure in China. [PDF]

Transbound Emerg Dis
The continuous emergence of circular Rep‐encoding single‐stranded (CRESS) DNA viruses across diverse hosts has been closely associated with the occurrence of severe diseases. Four circoviruses within the genus Circovirus have been identified in pigs, including porcine circovirus Type 1 (PCV1), PCV2, PCV3, PCV4, and PCV5.
Liu X, Li Y, Xiao J, Zhang X, Liu Y, Li Z, Wang L, Zhang L, Liu Y, Liang P, Xu Z, Liu Y, Song C.   +12 more
europepmc   +2 more sources

Annexin A2 facilitates porcine circovirus type 2 infection by mediating viral attachment to host cells and interacting with the capsid protein [PDF]

Veterinary Research
Porcine circovirus type 2 (PCV2) causes substantial economic losses globally. Although glycosaminoglycans (GAGs) have been identified as the general cell receptors responsible for PCV2 binding and subsequent cell infection, other critical protein(s) may ...
Yifan Jiang, Xinnuo Lei, Weijiao Liu, Siyu Cao, Qing He, Xiaohong Xie, Yang Zhan, Lei Tan, Jinhui Mai, Lingchen Yang, Aibing Wang, Yi Yang, Naidong Wang   +12 more
doaj   +2 more sources

Synergistic Pathogenicity by Coinfection and Sequential Infection with NADC30-like PRRSV and PCV2 in Post-Weaned Pigs

Viruses, 2022
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus (PCVs) are two major viruses that affect pigs. Coinfections between PRRSV and PCV2 are frequently reported in most outbreaks, with clinical presentations involving dyspnea,
Jinyong Zhang, Peng Wang, Changzhan Xie, Zhuo Ha, Ning Shi, He Zhang, Zhuoxin Li, Jicheng Han, Yubiao Xie, Xiangshu Qiu, Yimo Tao, Ningyi Jin, Huijun Lu   +12 more
doaj   +1 more source

Immune Molecules’ mRNA Expression in Porcine Alveolar Macrophages Co-Infected with Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2

Viruses, 2023
Porcine reproductive and respiratory syndrome virus (PRRSV) and porcine circovirus 2 (PCV2) are economically important pathogens in swine, and pigs with dual infections of PCV2 and PRRSV consistently have more severe clinical symptoms and interstitial ...
Zhiying Cui, Likun Zhou, Xingxing Hu, Shijie Zhao, Pengli Xu, Wen Li, Jing Chen, Yina Zhang, Pingan Xia   +8 more
doaj   +1 more source