A Comparison of Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with PCV2 and Porcine Reproductive and Respiratory Syndrome Virus [PDF]
Pathogens, 2021 The aim of this study was to compare the virulence of porcine circovirus type 2 (PCV2) genotypes in dually inoculated pigs with both three genotypes (a, b, and d) of PCV2 and porcine reproductive and respiratory syndrome virus-2 (PRRSV-2) versus pigs singularly inoculated with the same three PCV2 genotypes (a, b, and d).
Jeongmin Suh, Taehwan Oh, Siyeon Yang
exaly +5 more sources
A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with Mycoplasma hyopneumoniae and PCV2 [PDF]
Pathogens, 2021 The objective of this study was to compare the virulence of three different porcine circovirus type 2 (PCV2) genotypes (PCV2a, PCV2b, and PCV2d) in pigs infected with either one of these three PCV2 genotypes versus pigs dually inoculated with Mycoplasma hyopneumoniae and PCV2. Pigs were inoculated intratracheally with M. hyopneumoniae at 4 weeks of age
Taehwan Oh, Jeongmin Suh, Siyeon Yang
exaly +5 more sources
Structural roles of PCV2 capsid protein N-terminus in PCV2 particle assembly and identification of PCV2 type-specific neutralizing epitope [PDF]
PLOS Pathogens, 2019 Postweaning multisystemic wasting disease (PMWS) in piglets caused by porcine circovirus type 2 (PCV2) is one of the major threats to most pig farms worldwide. Among all the PCV types, PCV2 is the dominant genotype causing PMWS and associated diseases. Considerable efforts were made to study the virus-like-particle (VLP) assembly and the specific PCV2 ...
Xiaobing Mo +5 more
openaire +4 more sources
Concomitant Infection With Porcine circovirus 2 and Porcine Epidemic Diarrhea Virus Does Not Increase Enteritis Severity in Experimentally Infected Weaned Piglets. [PDF]
Transbound Emerg DisBackground Young pigs are often coinfected with porcine circovirus 2 (PCV2) and porcine epidemic diarrhea virus (PEDV). This study aimed to determine the impact of coinfection of pigs with PCV2 and PEDV. Forty 16‐day‐old crossbred mixed‐sex piglets were assigned to four groups (n = 10/group, NEG‐CONTROL, PCV2‐CONTROL, PCV2+PEDV, and PEDV‐CONTROL).
Gerber PF +6 more
europepmc +2 more sources
Development of Magnetic Particle-Based Chemiluminescence Immunoassays for Detecting PCV2 VLP- and Rep-Specific Antibodies and Their Combined Use for Immune Evaluation and Replication-Associated Exposure Assessment. [PDF]
Transbound Emerg DisPorcine circovirus 2 (PCV2) remains a major swine pathogen, and interpretation of capsid protein (Cap)–based serology is challenging in vaccinated populations because vaccine‐induced Cap antibodies overlap with replication‐associated serological signals.
Gou M +7 more
europepmc +2 more sources
Engineered PCV2 VLPs for Antigen Delivery: A Platform for Next-Generation Veterinary Vaccines. [PDF]
Transbound Emerg DisThe capsid (Cap) protein of porcine circovirus type 2 (PCV2) self‐assembles into virus‐like particles (VLPs) that form stable, noninfectious nanoparticles with T = 1 icosahedral symmetry. Mimicking native virion architecture, these VLPs display antigens in a highly ordered array, conferring strong immunogenicity for both humoral and cellular responses.
Ding P, Liu Y, Wang C, Wang A.
europepmc +2 more sources
Molecular Surveillance and Evolutionary Dynamics of Porcine Circovirus Types 2 and 3 in China, 2022-2025. [PDF]
Transbound Emerg DisPorcine circovirus types 2 (PCV2) and 3 (PCV3) are globally distributed pathogens associated with reproductive disorders, subclinical infections, and multifactorial disease complexes in swine. To elucidate their epidemiological and evolutionary patterns in China, we examined 8426 clinical samples collected from 28 provincial‐level regions between 2022 ...
Chen Y +11 more
europepmc +2 more sources
Emerging Challenges and Advances in Porcine Circovirus: A Decade in Review. [PDF]
Transbound Emerg DisOver the past decade, porcine circoviruses (PCVs) have continued to pose a significant threat to global swine health, and pivotal discoveries have significantly reshaped our understanding of their biology and control. Extensive genomic surveillance has expanded porcine circovirus 2 (PCV2) genotyping from four to at least eight lineages, with PCV2d now ...
Zheng J, Zhang G, Li P, Ren L.
europepmc +2 more sources
Field Evaluation of a Novel Combined Vaccine Against Porcine Circovirus Types 2a/d, Mycoplasma hyopneumoniae and Mycoplasma hyorhinis With an Emphasis on Growth Performance. [PDF]
Vet Med SciA field trial on three commercial farms evaluated a combined vaccine targeting PCV2a/d, Mycoplasma hyopneumoniae, and Mycoplasma hyorhinis. Vaccinated pigs showed improved average daily weight gain, stronger immune responses against these pathogens, and significantly reduced viral and mycoplasmal loads and lesion severity, supporting its efficacy under
Suh J +7 more
europepmc +2 more sources
Emergence of a Novel CRESS-DNA Virus Associated with Swine Reproductive Failure in China. [PDF]
Transbound Emerg DisThe continuous emergence of circular Rep‐encoding single‐stranded (CRESS) DNA viruses across diverse hosts has been closely associated with the occurrence of severe diseases. Four circoviruses within the genus Circovirus have been identified in pigs, including porcine circovirus Type 1 (PCV1), PCV2, PCV3, PCV4, and PCV5.
Liu X +12 more
europepmc +2 more sources