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Nature Cell Biology, 2020
PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.
Alison Jaccard, Ping-Chih Ho
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PD-L1 has been extensively described as the membrane-bound ligand of PD-1. A recent study discovered a previously unknown role for PD-L1, which is able to bind DNA and thus govern different pathways linked to either evasion of immune surveillance or tumour microenvironment inflammation.
Alison Jaccard, Ping-Chih Ho
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Arkhiv patologii, 2019
To investigate the expression of PD-L1 in triple-negative and luminal B, HER2-negative breast carcinoma and to assess the association of the tumor PD-L1 status with the prognosis of the disease.The PD-L1-status of primary tumor was studied in 72 patients with breast cancer, by using an immunohistochemical method.Differences were found in the incidence ...
G A, Frank +8 more
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To investigate the expression of PD-L1 in triple-negative and luminal B, HER2-negative breast carcinoma and to assess the association of the tumor PD-L1 status with the prognosis of the disease.The PD-L1-status of primary tumor was studied in 72 patients with breast cancer, by using an immunohistochemical method.Differences were found in the incidence ...
G A, Frank +8 more
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RSC Medicinal Chemistry
This review clarifies the evolution of PD-L1 inhibitors and provides insights into the current development of PD-L1 inhibitors, especially targeting internalization and degradation of PD-L1.
Jiazheng Guo +5 more
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This review clarifies the evolution of PD-L1 inhibitors and provides insights into the current development of PD-L1 inhibitors, especially targeting internalization and degradation of PD-L1.
Jiazheng Guo +5 more
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Immunotherapy, 2017
Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. Binding of PD-1 to its ligand, PD-L1, leads to protection against self-reactivity. In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor ...
Kuol, Nyanbol +3 more
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Expression of PD-1 on T/B cells regulates peripheral tolerance and autoimmunity. Binding of PD-1 to its ligand, PD-L1, leads to protection against self-reactivity. In contrary, tumor cells have evolved immune escape mechanisms whereby overexpression of PD-L1 induces anergy and/or apoptosis of PD-1 positive T cells by interfering with T cell receptor ...
Kuol, Nyanbol +3 more
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Science Signaling, 2017
As well as being an immunosuppressive checkpoint, the tumor-associated cell surface molecule PD-L1 suppresses pain signaling in sensory neurons.
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As well as being an immunosuppressive checkpoint, the tumor-associated cell surface molecule PD-L1 suppresses pain signaling in sensory neurons.
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[PD-L1 expression and PD-1/PD-L1 inhibitors in breast cancer].
Bulletin du cancer, 2018The development of immune checkpoints inhibitors represents one of the major recent advances in oncology. Monoclonal antibodies directed against the programmed cell death protein 1 (PD-1) or its ligand (PD-L1) provides durable disease control, particularly in melanoma, lung, kidney, bladder and head and neck cancers.
Audrey, Monneur +2 more
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PD-L1/2: ???????????????????????? ???????????????? ?? ??????????????????
2019???????? ????????????: ???????????? ???????????????? ???????????????????? ???????? ???????????????????????????? ???????????????? ?????????????????? ???????????? PD-L1/2 (program death ligand) ???? ???????????????? ???????????????????? ???????????????????????? (????) ?????????????? ?????????????????????? ???? ??????????????????????. ?????????????????? ??
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Mitochondrial PD-L1 modulates cancer immunotherapy
Cell Research, 2023Xiaoming Dai, Jing Liu, Wenyi Wei
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