Results 131 to 140 of about 1,895,251 (293)
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
Xi'an Gongcheng Daxue xuebaoTo enhance the electrocatalytic performance of the Pd catalyst for methanol, flexible PdAg@CFs catalysts were prepared using the impregnation reduction method with carbon fiber cloths (CFs) as the flexible carriers and Ag as the co-catalysts.In order to ...
SONG Yanyan +5 more
doaj +1 more source
In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans
FEBS Open Bio, EarlyView.In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller +3 more
wiley +1 more source
Pd/C-catalyzed Hiyama Cross-coupling Reaction [PDF]
, 2013 P(論文)檜山クロスカップリング反応は、フッ化物塩や塩基により活性化された有機ケイ素化合物と有機ハライド、あるい は有機ハライド等価体とのパラジウム（Pd）を触媒とした交差縮合反応である。本反応の基質である有機ケイ素化合物 は毒性が低く、またグリニャール試薬などの求核剤と異なり空気中安定で取り扱いやすい。また、反応後に副生するケイ 素化合物は、燃焼により無害な二酸化ケイ素に変換・処理されるため、檜山カップリングは医薬品を始めとした機能性物 質の量産化反応に適している。従来法では均一系Pd 触媒を使用し ...
SAJIKI, Hironao +23 more
core
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
, 2017 This figure shows that PD-L1 expression is not quantitatively altered on the anti-PD-1 resistant tumor cells, compared to parental tumor cells.
Ailin Li (1698712) +20 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub +24 more
wiley +1 more source
Obtenção, caracterização e avaliação da atividade de um nanocatalisador de Pd(0) sintetizado in situ sob a superfície de Fe3O4@dextrana para redução do 4-nitrofenol [PDF]
, 2015 Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Físicas e Matemáticas, Programa de Pós-Graduação em Química, Florianópolis, 2015.O objetivo principal deste trabalho é a preparação, caracterização e avaliação da atividade ...
Lara, Luciano Roni Silva
core
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source