Results 111 to 120 of about 1,895,251 (293)

Involvement of gut microbiota in neuropsychiatric disorders and its therapeutic potential

Journal of Animal Reproduction and Biotechnology
Accumulating evidence indicates that the gut microbiota plays a pivotal role in overall health through complex interactions along the gut-brain axis. The present study explores the intricate relationships between the gut microbiota and the gut-brain axis,
Sangmin Lee, Gyebin Lee, Yeung Bae Jin, Han-Na Kim, Joo Hyung Park, Hye Jin Cha   +5 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Preparation and Characterization of C@Fe3O4 Supported Pd Magnetic Nanoparticles for Degradation of Dye Wastewater

Medžiagotyra
The core-shell structure Fe3O4@C magnetic nanoparticles were synthesized with superparamagnetic Fe3O4 nanosphere as a magnetic core, and soluble starch resin as a carbon source via a solvothermal method. Silica-iron oxide and Fe3O4@C carriers with a core-
Xue FANG, Yang WANG, Xianghong CUI, Shumeng ZHOU, Haijian JIANG, Meihuui SONG, Liming YAO, Xiaochen ZHANG   +7 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Nachweis der Immuncheckpoint-Komponenten PD-L1 und PD-1 in Tumor- und Immunzellen bei Patienten mit Nierentumoren

Die Immun-Checkpoint-Inhibition blockiert die ko-inhibitorische Interaktion zwischen Lymphozyten und Tumorzellen in der Tumormikroumgebung und stellt eine essentielle Therapieoption für metastasierte Krebserkrankungen, einschließlich Nierentumoren dar ...
Schultz, Carolin
core   +1 more source

Влияние модифицирующих добавок Pd, Pt и Au на сенсорные свойства SnO2 и In2O3 при определении паров ацетона

Журнал Белорусского государственного университета: Химия, 2023
Исследованы свойства планарных сенсоров на основе синтезированных нанопорошков диоксида олова и оксида индия при определении паров ацетона. Полученные сенсоры показали высокую чувствительность к низким концентрациям ацетона во влажной среде, моделирующим
Евгений Андреевич Оводок, Мария Ивановна Ивановская, Татьяна Васильевна Гаевская, Валентина Васильевна Кормош, Виталий Степанович Биланич   +4 more
doaj  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

DataSheet_1_A CD64/FcγRI-mediated mechanism hijacks PD-1 from PD-L1/2 interaction and enhances anti-PD-1 functional recovery of exhausted T cells.pdf

, 2023
Therapeutic monoclonal antibodies (mAb) targeting the immune checkpoint inhibitor programmed cell death protein 1 (PD-1) have achieved considerable clinical success in anti-cancer therapy through relieving T cell exhaustion.
Alessandra Noto (7022864), Constantinos Petrovas (517531), Michel Obeid (14229623), Craig Fenwick (1792990), Victor Joo (13318521), Giuseppe Pantaleo (10464), Laurence de Leval (135768)   +6 more
core   +1 more source

Propiedades metalúrgicas y electroquímicas de la aleación Au-1,7% Ti para aplicaciones odontológicas

Revista Facultad de Ingeniería Universidad de Antioquia, 2006
En el presente trabajo se evalúa la microestructura y la micro-dureza de una aleación Au-1,7% Ti en las condiciones centrifugada, solubilizada y con posterior envejecimiento a 400°C por 4 horas.
Hector Darío Sánchez, Jorge Andrés Calderón, Alejandro Echavarría, Lina Morales   +3 more
doaj  

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source