Results 91 to 100 of about 3,147,744 (277)

Partial Discharge in Electronic Equipments [PDF]

, 2009
Tato disertační práce se věnuje studiu částečných výbojů (PD) způsobených poklesem spolehlivosti a životnosti elektronických zařízení a systémů. Diagnostika PD je dnes známá metoda pro vysoké napětí u vysoko-výkonných zařízení.
Mammadov, Anar
core  

Finite size effects with variable range exchange coupling in thin-film Pd/Fe/Pd trilayers

, 2010
The magnetic properties of thin-film Pd/Fe/Pd trilayers in which an embedded ~1.5 A-thick ultrathin layer of Fe induces ferromagnetism in the surrounding Pd have been investigated.
A.F. Hebard, Aharoni, Bozorth, Cable, Chechenin, Cheng, Cheng, Crangle, Crangle, Farle, Huang, Li, Low, Lutz, Min, Moriya, Neel, Nieuwenh, Nieuwenhuys, Oswald, Pajda, R. Misra, R. Rairigh, R.K. Das, S. Tongay, Skomski, Stringfe, Tabakovic, Tang, Tiller, Tofail, Vaz, Wolf, Zhang   +33 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Biomass-supported catalysts on Desulfovibrio desulfuricans and Rhodobacter sphaeroides [PDF]

, 2008
A Rhodobacter sphaeroides-supported dried, ground palladium catalyst (‘‘Rs-Pd(0)’’) was compared with a Desulfovibrio desulfuricans-supported catalyst (‘‘Dd-Pd(0)’’)and with unsupported palladium metal particles made by reduction under H2 (‘‘Chem-Pd(0)’’)
Baxter-Plant, VS, Deplanche, K, Macaskie, LE, Redwood, MD   +3 more
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Increased markers of cardiac vagal activity in leucine-rich repeat kinase 2-associated Parkinson's disease. [PDF]

, 2019
PurposeCardiac autonomic dysfunction manifests as reduced heart rate variability (HRV) in idiopathic Parkinson's disease (PD), but no significant reduction has been found in PD patients who carry the LRRK2 mutation.
Carricarte Naranjo, Claudia, Cornforth, David J, Estévez, Mario, Goldman, Samuel M, Jelinek, Herbert F, Lang, Anthony E, Machado, Andrés, Marras, Connie, Sanchez-Rodriguez, Lazaro, Schüle, Birgitt, Stein, Phyllis K, Visanji, Naomi P   +11 more
core  

Involvement of gut microbiota in neuropsychiatric disorders and its therapeutic potential

Journal of Animal Reproduction and Biotechnology
Accumulating evidence indicates that the gut microbiota plays a pivotal role in overall health through complex interactions along the gut-brain axis. The present study explores the intricate relationships between the gut microbiota and the gut-brain axis,
Sangmin Lee, Gyebin Lee, Yeung Bae Jin, Han-Na Kim, Joo Hyung Park, Hye Jin Cha   +5 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source