Results 201 to 210 of about 291,222 (247)

Exploring the Structural Basis of Cryptic Pocket Formation Driven by Extensive Protein Conformational Changes in Drug Targets. [PDF]

J Chem Theory Comput
Bemelmans MP, Borsatto A, Marsili S, Gervasio FL, Pande V.   +4 more
europepmc   +1 more source

Trisoxazole Macrolides Potentiate the Microtubule Assembly and Antimitotic Activities of Taxanes

Angewandte Chemie, EarlyView.
Photoaffinity experiments identified tubulin as a new target of mycalolides. Though weakly cytotoxic, the trisoxazole macrolactone moiety enhanced paclitaxel's microtubule assembly and antimitotic effects. Molecular modeling studies suggested that MyC stabilizes α/β‐tubulin heterodimer interactions.
Shohei Ebihara, Rio Takaiso, Shota Kawaguchi, Atsunori Oshima, Masaki Kita   +4 more
wiley   +1 more source

Network-based allosteric analysis of galectin-7: Key residues dictate functional communication and stability. [PDF]

Protein Sci
Pham NTH, Paré A, Létourneau M, Fortier M, Chatenet D, St-Pierre Y, Lagüe P, Calmettes C, Doucet N.   +8 more
europepmc   +1 more source

The Isolated Thumb Domain of Acid‐Sensing Ion Channels Forms a Minimal Folding Unit Enabling Ligand Binding Studies

Angewandte Chemie, EarlyView.
An independently folded thumb domain from acid‐sensing ion channels (ASICs) preserves ligand‐binding and proton‐sensing properties. NMR‐based interaction and pKa analyses uncover how endogenous and exogenous peptides modulate ASICs, providing a simplified model for rational drug discovery targeting proton‐gated ion channels.
Biswa P. Mishra, Ben Cristofori‐Armstrong, Elena Budusan, Mimi Golder, Neville J. Butcher, Junyu Liu, Theo Crawford, Yanni K.‐Y. Chin, Anneka Pereira Schmidt, Xinying Jia, Taylor B. Smallwood, Richard J. Clark, Jan P. Wurm, Lachlan D. Rash, Mehdi Mobli   +14 more
wiley   +1 more source

Crystal structure of the histone heterodimer containing histone variant H2A.W. [PDF]

Biochem Biophys Rep
Hu S, Yang Y, Wang L, Xu L.
europepmc   +1 more source

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability

Angewandte Chemie, EarlyView.
Here, we show that well studied PET hydrolases can be re‐engineered via directed evolution to deconstruct alternative aromatic‐containing commodity polymers. Introduction of only three mutations into LCCICCG was sufficient to generate an efficient polycarbonate hydrolase with high operational stability that can fully depolymerize a polycarbonate sample
Henry A. Jones, Amy E. Hutton, Dominic Harris‐Jukes, John Davidson, Linus O. Johannissen, Colin W. Levy, Michael P. Shaver, Anthony P. Green   +7 more
wiley   +1 more source

Aminoacyl-tRNA-dependent enzymes in natural product biosynthesis: structure-function insights. [PDF]

J Antibiot (Tokyo)
Zheng Y, Zhao Y, Takahashi S.
europepmc   +1 more source

Regiodivergent C3 and C4 Amination of Quinolines via Radical and Ionic Pathways

Angewandte Chemie, EarlyView.
A regiodivergent strategy converts a single N‐aminoquinolinium precursor into either C3‐ or C4‐aminated quinolines. Nucleophile‐induced dearomatization diverges into light‐driven N‐centered radical capture (C3) or base‐promoted SNAr (C4), enabling rapid assembly of aminoquinoline libraries and late‐stage diversification.
Ye‐Eun Kim, Jieun Kim, Juyeon Lee, Sungwoo Hong   +3 more
wiley   +1 more source

In silico identification of bilobetin and ginsenoside as dual CK2 and ULK2 inhibitors targeting triple-negative breast cancer. [PDF]

Sci Rep
Hossain MA, Tamanna IJ, Hossain MS, Parvez A, Afrin S, Sobuj DR, Islam MT, Al Noman A, Ahmed M, Sultana S, Srivastava S, Rao GSNK, Khan SR, Babu MR, Tariq M, Saiyad MT, Hamzah Z, Jain M.   +17 more
europepmc   +1 more source