Results 181 to 190 of about 326,099 (315)

Crystal structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+

, 2021
Steiner, R. A., Onesti, S., Napolitano, L. M. R., De March, Matteo   +3 more
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

The Effects of Bisphosphonates Used in Osteoporosis Treatment on Breast Cancer: Analysis with Integrative Bioinformatics Methods, DFT, ADMET and Molecular Docking Analysis. [PDF]

Biology (Basel)
Dogan SC, Goren K.
europepmc   +1 more source

Modulation of PCNA sliding surface by p15PAF suggests a suppressive mechanism for cisplatin-induced DNA lesion bypass by pol eta holoenzyme

, 2021
Mentegari, E., Crehuet, R., Onesti, S., Merino, N., De Biasio, A., Bressan, E., Barrera-Vilarmau, S., De March, Matteo, Maga, G., Blanco-Silva, Francisco J.   +9 more
core   +1 more source

Kinsenoside Targets IDH1 to Restore Microglial Immune‐Metabolic Homeostasis for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
Dysregulated TCA cycle contributes to Alzheimer's disease (AD) pathogenesis. Here, we show that microglial isocitrate dehydrogenase 1 (IDH1) is a critical driver. Elevated IDH1 disrupts citrate metabolism and mitochondrial function, exacerbating AD pathology.
Qianqian Li, Yajin Liao, Yan‐bo Zhao, Hongxing Wu, Tong Jin, Shuoshuo Li, Yuhan Liu, Peng Li, Songying Ouyang, Zekai Li, YuTing Xia, Qian Hua, Rui‐Yuan Pan, Zengqiang Yuan   +13 more
wiley   +1 more source

Crystal structure of 3\u27-5\u27 RecJ exonuclease from M. Jannaschii

, 2021
Saha, I., Onesti, S., Medagli, Barbara, Pisani, F., Krastanova, I., De March, Matteo   +5 more
core   +1 more source

SDS‐CRISPR for Single‐Nucleotide Variant Detection

Advanced Science, EarlyView.
Structure‐disruption‐sensitive CRISPR (SDS‐CRISPR) converts structural instability into single‐nucleotide precision, thereby overcoming mismatch tolerance in canonical Cas12a and enabling versatile diagnostics across DNA, RNA, and microRNA targets. When applied to rapid IDH1 mutation detection for glioma genotyping and integrated with lateral‐flow ...
Xin Guan, Chong Guo, Jiongyu Zhang, Rui Yang, Yerramsetti Ramachandra, Chengyu Hou, Minjie Pei, Shuo Zhang, Kurt T. Schalper, Xingye Liu, Qian Wu, Ketan R. Bulsara, Changchun Liu   +12 more
wiley   +1 more source

PDB BLAST [PDF]

, 2020
openaire   +1 more source

Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71. [PDF]

Sci Adv
Zhou D, Kotecha A, Kelly JT, Huang PN, Chen YY, Walter TS, Duyvesteyn HME, Owens RJ, Ho SY, Lin TY, Fry EE, Ren J, Huang KA, Stuart DI.   +13 more
europepmc   +1 more source

The experimental X-ray structure of the new diheme cytochrome type c from Shewanella baltica OS155 sb-DHC

, 2021
Di Rocco, G., Geremia, S., De March, Matteo   +2 more
core   +1 more source