Results 161 to 170 of about 344,397 (313)

Crystal structure of CNG mimicking NaK-ETPP mutant cocrystallized with Li+

, 2021
Onesti, S., Napolitano, L. M. R., De March, Matteo   +2 more
core   +1 more source

TRAF6 Lactylation in Glycolytic Macrophages Drives NF‐κB Signaling and M1 Polarization During Orthodontic Tooth Movement

Advanced Science, EarlyView.
Schematic diagram showing compressive stress triggers glycolytic reprogramming and lactate accumulation in macrophages. Lactate mediates TRAF6 lactylation at K171/K180 dual sites, which enhances its K63‐linked ubiquitination to activate the NF‑κB pathway and promote M1 polarization. This cascade drives orthodontic tooth movement (OTM) and alveolar bone
Xinyi He, Guodong Zhao, Yun Hu, Wenya Bai, Hao Tan, Shuai Yuan, Sihan Yang, Ye Zhu, Xiaohui Xu, Leilei Zheng   +9 more
wiley   +1 more source

Soluble protein analog selection engine (SPASE): An automated AI-powered server to improve protein engineering workflows. [PDF]

Protein Sci
Larda ST, Paré A, Doucet N.
europepmc   +1 more source

Crystal structure of CNG mimicking NaK-ETPP mutant in complex with Na+

, 2021
Onesti, S., Napolitano, L. M. R., De March, Matteo   +2 more
core   +1 more source

AlfB fucosidase in complex with Fucose [X-RAY DIFFRACTION 2.30 Å]

Usage Policies The wwPDB policy states that data files contained in the PDB archive are available under the CC0 1.0 Universal (CC0 1.0) Public Domain DedicatioMinisterio de Ciencia e Innovación (MCIN)9HYX.pdbPeer ...
Marina, Alberto, Gallego del Sol, Francisca   +1 more
core   +1 more source

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

Advanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv, Ziqi Feng, Qi Wen Teo, Chunke Chen, Akshita B. Gopal, Danbi Choi, Timothy J. C. Tan, Yun Sang Tang, Lewis Siu, Armita Nourmohammad, Roberto Bruzzone, Ian A. Wilson, Meng Yuan, Nicholas C. Wu, Chris K. P. Mok   +14 more
wiley   +1 more source

Happy anniversary, PDB! [PDF]

Nature Structural & Molecular Biology, 2021
openaire   +2 more sources

Avoiding pitfalls when modelling ligands in macromolecular crystallography. [PDF]

Acta Crystallogr D Struct Biol
Smart OS, Sharff A, Flensburg C, Vonrhein C, Bricogne G.   +4 more
europepmc   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Thymol and Limonene as Potent Antimicrobials: Bridging In Vitro Efficacy and Molecular Docking Insights. [PDF]

Int J Microbiol
Benkhaira N, El Fadili M, Koraichi SI, Fikri-Benbrahim K.   +3 more
europepmc   +1 more source