Results 171 to 180 of about 344,397 (313)

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants

, 2017
This record links to 4 protein structures determined by x-ray crystallography, deposited in the RCSB ...
Huang, Danny, Nakasone, Mark, Sibbet, Gary, Gabrielsen, Mads, Smith, Brian, Zhang, Wei, Sidhu, Sachdev, Buetow, Lori, Ahmed, Syed   +8 more
core  

Revolutionising Agricultural Sustainability: New ‘Furrow Tillage’ can Mitigate Short‐Term Soil‐to‐Atmosphere CO2 Flux and Promote Soil‐Plant‐Microbe Health

Advanced Science, EarlyView.
Furrow tillage resolves the conventional‐vs.‐no‐tillage trade‐off by simultaneously cutting CO2 efflux to 2.0–3.0 g C m−2 d−1 and unlocking high nutrient availability for the rice rhizosphere. This scalable agronomic solution strengthens soil health, enhances plant physiology, reshapes microbial metabolism, and shifts paddy systems toward a net ...
Arnab Majumdar, Munish Kumar Upadhyay, Argha Ghosh, Rakesh Biswas, Ioly Kotta Loizou, Martin Buck, Mark Tibbett, Biswajit Giri, Debojyoti Moulick, Manoj Kumar Jaiswal, Tarit Roychowdhury   +10 more
wiley   +1 more source

Parallel PDB Data Retriever 'PDB Diving Booster'

Parallel PDB Data Retriever 'PDB Diving Booster'
identifier:oai:t2r2.star.titech.ac.jp ...
openaire   +1 more source

Blood Pressure and Systemic Risk Factors in Patients Presenting With Post-Extraction and Periodontal Bleeding at a Dental Out-of-Hours Clinic. [PDF]

Clin Exp Dent Res
Iijima Y, Yamada M, Hino S, Sano M, Horie N, Kaneko T.   +5 more
europepmc   +1 more source

Crystal structure of CNG mimicking NaK mutant, NaK-ETPP, Cs+ complex

, 2021
Onesti, S., Napolitano, L. M. R., De March, Matteo   +2 more
core   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Protein Data Bank Japan: A unified portal for integrating structural and chemical data to explore protein-ligand interactions in PDB and PubChem. [PDF]

Protein Sci
Bekker GJ, Nagao C, Niwa S, Kurisu G.
europepmc   +1 more source

Crystal structure of CNG mimicking NaK-EAPP mutant (T67A) cocrystallized with K+

, 2021
Steiner, R. A., Onesti, S., Napolitano, L. M. R., De March, Matteo   +3 more
core   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source