Results 31 to 40 of about 972,039 (207)

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

Study on kinematic characteristics of the vertical-wheel on hybrid PDC bit

Advances in Mechanical Engineering, 2022
Aiming at improving the ROP of PDC bits in hard-to-drill formation, a new hybrid PDC bit with vertical-wheel is proposed in this paper, furtherly, the kinematic characteristics of the vertical-wheel are researched.
Qingliang Qi, Yingxin Yang, Yan Yang, Shi-Wei Niu, Xinfa Chen   +4 more
semanticscholar   +1 more source

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

Advanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang, Xinyu Tang, Zeju Li, Qi Qi, Chang Sun, Wen Sun, Weiya Zhang, Yue Yin, Ya Deng, Peiwen Ling, Yifan Xu, Guangshun Sun, Yi Ren, Hong Pan, Shui Wang, Wenbin Zhou   +15 more
wiley   +1 more source

Reverse Engineering of PDC Drill Bit [PDF]

, 2013
Reverse engineering (RE) is a very important technology especially in geometrically design and manufacture application area where this technique has been widely recognized as an important step in products and systems. This study is focus on the PDC drill
Mohd Zolkafly, Muhammad Ariff Zaky
core  

Impact of PDC Bit Design on Stick-Slip

, 2010
Drillstrings are affected by different types of harmful vibrations particularly stick-slip which is characterized by PDC drill bits intense rotary speed fluctuations.
Pelfrene, Gilles
core   +2 more sources

New Progress and Future Development of PDC Bit

Shiyou jixie, 2016
A series of new PDC bits have been developed in foreign countries in order to raise rock breaking efficiency, extend bit service life and reduce trips, drilling cycle and drilling cost.
Pan Jun, Wang Minsheng, Guang Xinjun
doaj  

Novel Interdigitated Electrode Conductometric Sensor for Rapid, Sensitive, and Selective Detection of cTnI Biomarkers in Saliva

Advanced NanoBiomed Research, EarlyView.
A miniaturized high resistivity silicon‐based interdigitated conductometric sensor detects cTnI at sub‐femtomolar levels with high selectivity. The device enables noninvasive testing using artificial and pooled human saliva in real‐time electrical readings. This portable biosensor offers a promising futuristic medical device providing new opportunities
Preethi Chidambaram, Fateme Akhlaghi Bagherjeri, Ganganath S. Perera, Rajour Tanyi Ako, Sreekanth S. P, Chenglong Xu, Sharath Sriram, Shanmuga Sundar Dhanabalan, Madhu Bhaskaran   +8 more
wiley   +1 more source

Experimental study of layouts of PDC cutters in core bit drilling [PDF]

, 2016
Over the past two decades, various single cutter force models have been developed that consider formation properties and bit characteristics. These models have been extensively used to describe the interaction of a Polycrystalline Diamond Compact (PDC ...
Miska, S. Z., Ziaja, M. B., Buitrago Gomez, L. A.   +2 more
core   +1 more source

Analysis of Stick-Slip Vibration of PDC Bit under Sudden Increase of Formation Hardness

Shiyou jixie, 2019
In drilling an interbedded soft and hard formation with PDC bit, it is prone to cutter crack and damage. To address the issue, the stick-slip vibration characteristics of PDC bit during the sudden increase of formation hardness were studied.
Zha Chunqing, Chen Jie, Zhao Jincheng, Liu Gonghui   +3 more
doaj  

Research on numerical drilling technology of mesh-like cutting PDC bit

, 2021
Numerical simulation on rock-breaking and drilling has been developed as a novel technic for designing and performance analyzing of the bit. On basis of theoretical research and experimental test on the mesh-like cutting PDC bit, the numerical model of ...
Chun-Liang Zhang, Yingxin Yang, Qingliang Qi, H. Ren, Jincheng Wang   +4 more
semanticscholar   +1 more source