Results 81 to 90 of about 18,799 (212)

The Role of N6‐Methyladenosine Modification in Health and Disease

MedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li, Yuanhai Sun, Wanfang Zheng, Lingqin Li, Yaqian Feng, Minyou Qi, Hanbing Li   +6 more
wiley   +1 more source

Synergizing FMEA and PDCA for superior risk management and process improvement in the semiconductor industry: a case study

International Journal of Production Management and Engineering
The semiconductor industry faces the dual challenge of risk assessment and process improvement. This paper introduces a framework that integrates Failure Mode and Effects Analysis (FMEA) and Plan-Do-Check-Act (PDCA) cycle to address these challenges ...
Ding Hock Hii, Nur Amalina Muhammad, Noorhafiza Muhammad   +2 more
doaj   +1 more source

Identification of 2‐Substituted‐3‐Hydroxy‐2,3‐Dihydroquinazolin‐4(1H) Ones as Cell‐Active Inhibitors of KDM4A Lysine Demethylase

ChemMedChem, Volume 21, Issue 10, 27 May 2026.
A novel 3‐hydroxy‐2,3‐dihydroquinazolinone scaffold is identified as a cell‐active KDM4A inhibitor through an orthogonal screening cascade minimizing assay interference. Integrated biochemical, biophysical, and proteomic validation reveals compound 6i as a bona fide binder that increases H3K9 methylation in cells, highlighting both a promising ...
Alessandra Feoli, Amodio Luca Balzano, Ida Pacilio, Alessandra Cipriano, Roman Belle, Giacomo Pepe, Manuela Giovanna Basilicata, Pietro Campiglia, Fabrizio Micheli, Akane Kawamura, Ciro Milite, Sabrina Castellano, Axel Imhof, Gianluca Sbardella   +13 more
wiley   +1 more source

Clinical application and nursing experience of the plan-do-check-act cycle in daytime varicocelectomy

BMC Nursing
Background Varicocele is the most prevalent correctable cause of male infertility. Currently, surgical treatment is the primary method to enhance fertility.For many young varicocele patients who have postponed surgery due to time constraints, daytime ...
Kang He, Jianxiong Li, Cheng Yang, Junping Wu, Biling Wu, Hui Xia   +5 more
doaj   +1 more source

The Culture Clash of AI Adoption in Lean Quality Management. Resolving the Tensions at Siemens Electronics Works Amberg

Information Systems Journal, Volume 36, Issue 3, Page 315-339, May 2026.
ABSTRACT Artificial intelligence (AI) brings great potential for manufacturers, but clashes with the established culture due to the unexplainable and opaque nature of the solutions it provides. Having little experience in AI and machine learning (ML), most manufacturing leaders experience barriers implementing AI.
Benjamin van Giffen, Gunter Beitinger, Helmuth Ludwig, Bill Schiano, Konstantin Schmidt, Jan vom Brocke   +5 more
wiley   +1 more source

A Three‐Step Route to Functionalized Pyrrole‐2,5‐Dicarboxylic Acids from Galactaric Acid

ChemSusChem, Volume 19, Issue 8, 28 April 2026.
Galactaric acid (GalA) has been used as substrate for a library of N‐substituted pyrrole‐2,5‐dicarboxylic acids (PDCAs). Existing routes to N‐substituted PDCAs require many steps or lack product isolation. We present a simple, scalable three‐step synthesis from GalA via a 2‐pyrone salt, giving isolated PDCA derivatives in high yield without ...
Giacomo Trapasso, Davide Dalla Torre, Marco Artuso, Fabio Aricò   +3 more
wiley   +1 more source

Quality assurance in planning a radon measurement survey using PDCA cycle approach: what improvements?

International Journal of Metrology and Quality Engineering, 2019
This work is focused on effectiveness of adopting the Plan, Do, Check, Act (PDCA) cycle model, also known as Deming cycle, for an analytical laboratory management.
La Verde Giuseppe, Roca Vincenzo, Pugliese Mariagabriella   +2 more
doaj   +1 more source

Effect of PDCA cycle on reducing the turnover time for MAKO robot-assisted total knee arthroplasty surgeries (运用PDCA循环缩短MAKO机器人辅助膝关节置换接台手术时间)

中西医结合护理
Objective To analyze the effect of the Plan-Do-Check-Act (PDCA) cycle method on reducing the preoperative preparation time for MAKO robot-assisted knee arthroplasty in consecutive surgeries.
HAO Dexia (郝德霞), FENG Haiping (冯海萍), GE Suli (葛素利), YANG Qun (杨群)   +3 more
doaj   +1 more source

The US space station and its electric power system [PDF]

The United States has embarked on a major development program to have a space station operating in low earth orbit by the mid-1990s. This endeavor draws on the talents of NASA and most of the aerospace firms in the U.S. Plans are being pursued to include
Thomas, Ronald L.
core   +1 more source

Total Quality Management: Analysis, Evaluation and Implementation Within ACRV Project Teams [PDF]

, 1991
Total quality management (TQM) is a cooperative form of doing business that relies on the talents of everyone in an organization to continually improve quality and productivity, using teams and an assortment of statistical and measurement tools.
Raiman, Laura B.
core   +1 more source