Results 71 to 80 of about 24,413 (219)

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Rivastigmine for the treatment of dementia associated with Parkinson’s disease

Neuropsychiatric Disease and Treatment, 2007
Jennifer L Reingold, John C Morgan, Kapil D SethiMovement Disorders Program, Department of Neurology, Medical College of Georgia, Augusta, GA, USAAbstract: Parkinson’s disease (PD) afflicts millions of people worldwide and leads to cognitive ...
Jennifer L Reingold, John C Morgan, Kapil D Sethi   +2 more
doaj  

Fear of falling is associated with physical functioning, activity performance, and participation in individuals with multiple sclerosis

PM&R, EarlyView.
Abstract Background Fear of falling (FoF) is a common concern in individuals with multiple sclerosis (MS). Understanding whether and how FoF affects activities and participation is crucial for developing effective rehabilitation programs in individuals with MS.
Libak Abou, Jeeyeon Kim, Chloe McCloskey, Cory Wernimont, Anna L. Kratz   +4 more
wiley   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Variations in the diagnostic performance of transurethral resection of bladder tumor with photodynamic diagnosis according to surgical experience: A retrospective, single-center study

Photodiagnosis and Photodynamic Therapy
Background: To investigate variations in diagnostic performance of photodynamic diagnosis (PDD) according to surgical experience. Methods: Data were extracted from patients having pT1 or lower primary tumors that underwent PDD-assisted transurethral ...
Shuhei Suzuki, Yoshiyuki Nagumo, Kosuke Kojo, Atsushi Ikeda, Bunpei Isoda, Akane Yamaguchi, Kozaburo Tanuma, Satoshi Nitta, Masanobu Shiga, Takashi Kawahara, Shuya Kandori, Akio Hoshi, Hiromitsu Negoro, Bryan J. Mathis, Hiroyuki Nishiyama   +14 more
doaj   +1 more source

Narrow band imaging‐guided diode laser ablation in recurrent low‐grade non‐muscle‐invasive bladder cancer

UroPrecision, EarlyView.
Abstract Background Low‐grade non‐muscle‐invasive bladder cancer (NMIBC) is characterized by high recurrence rates, resulting in repeated interventions and intensive surveillance. Office‐based transurethral laser ablation (TULA) performed under local anesthesia is a minimally invasive alternative to transurethral resection, and narrow band imaging (NBI)
Ibrahim A. Khalil, Ahmed B. Altayeb, Majd AlKabbani, Nagy Younes, Alaeddin Badawi, Ahmad R. Al‐Qudimat, Khalid AlRumaihi   +6 more
wiley   +1 more source

Surface‐driven size scaling of the lattice parameter, Debye–Waller coefficient and microstrain in nanocrystals

Acta Crystallographica Section A, EarlyView.
This work develops three surface‐driven nanoscale models for the diffraction‐derived lattice parameter, Debye–Waller coefficient and microstrain, clarifying why their size dependences are not equally universal. Atomistic simulations and literature data show that lattice parameter trends depend strongly on capillarity, chemistry and defects, whereas the
Sirisha Subbareddy, Erick Agnolin, Marcelo Augusto Malagutti, Narges Ataollahi, Robert Dinnebier, Paolo Scardi   +5 more
wiley   +1 more source

The clinical effectiveness of a self-management intervention for patients with persistent depressive disorder and their partners/caregivers: results from a multicenter, pragmatic randomized controlled trial

Trials
Background Persistent depressive disorder (PDD) is prevalent and debilitating. For patients with PDD, psychiatric rehabilitation using self-management interventions is advised as the next therapeutic step after multiple unsuccessful treatment attempts ...
Ericka C. Solis, Ingrid V. E. Carlier, Noëlle G. A. Kamminga, Erik J. Giltay, Albert M. van Hemert   +4 more
doaj   +1 more source

Psychedelic‐assisted treatment for substance use disorder: A narrative systematic review

Addiction, EarlyView.
Abstract Background and aims This is the first systematic review of the extant literature on all major psychedelic‐assisted treatment for alcohol use disorder (AUD), tobacco use disorder (TUD) and other substance use disorders (SUD). We aimed to summarise the evidence for efficacy of psychedelic‐assisted treatment for AUD, TUD, and SUD; to evaluate its
Theodore Piper, Francesca Small, Sam Brown, Michael Kelleher, Luke Mitcheson, James Rucker, Allan H. Young, John Marsden   +7 more
wiley   +1 more source

Discovery of potent kinase inhibitors with improved pharmacokinetics and safety potentials through structural optimization of dasatinib

Communications Medicine
Background Dasatinib exhibits broad therapeutic potentials for several diseases; however, its clinical application is limited by safety concerns and unfavorable pharmacokinetics. Methods Structural optimization of dasatinib yielded PDD-87.
Kan He, Lining Cai
doaj   +1 more source