Results 151 to 160 of about 33,386 (268)

Retraction: Effect of rumex dentatus on gastrointestinal protection and toxicology in rodents via investigating H+/K+-ATPase, calcium channels, and PDE mediated signaling. [PDF]

Front Pharmacol
Frontiers Editorial Office.
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, EarlyView.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

The finite element neural network method to simulate two dimensional partial differential equations and perform parameter identification. [PDF]

Sci Rep
Abda M, Berthet L, Hamedi M, Hibatullah D, Piollet E, Blake C, Blais B, Gosselin FP.   +7 more
europepmc   +1 more source

Adenosine A2A receptor (ADORA2A); phosphodiesterase-2 (PDE-2); PDE-3; PDE-4; PDE-7 [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, EarlyView.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source

Data-driven, ML-assisted approaches to problem well-posedness. [PDF]

PNAS Nexus
Bertalan T, Kevrekidis GA, Koronaki ED, Mishra S, Rebrova E, Kevrekidis IG.   +5 more
europepmc   +1 more source

PDE

Plan for dissemination and exploitation incl.
openaire   +1 more source

Computing Skinning Weights via Convex Duality

Computer Graphics Forum, EarlyView.
We present an alternate optimization method to compute bounded biharmonic skinning weights. Our method relies on a dual formulation, which can be optimized with a nonnegative linear least squares setup. Abstract We study the problem of optimising for skinning weights through the lens of convex duality.
J. Solomon, O. Stein
wiley   +1 more source

Biological implications and therapeutic potential of phosphodiesterase inhibitors: A review. [PDF]

Medicine (Baltimore)
Alnazari M, Bakhsh A, Abdullah S, Al Qahtani S, Borhan W, Rajih E, Alshehri AM.   +6 more
europepmc   +1 more source

SDFs from Unoriented Point Clouds using Neural Variational Heat Distances

Computer Graphics Forum, EarlyView.
We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from unoriented point clouds. We first compute a small time step of heat flow (middle) and then use its gradient directions to solve for a neural SDF (right). Abstract We propose a novel variational approach for computing neural Signed Distance Fields (SDF) from ...
Samuel Weidemaier, Florine Hartwig, Josua Sassen, Sergio Conti, Mirela Ben‐Chen, Martin Rumpf   +5 more
wiley   +1 more source